Evidence map›Paper›PMID 39453913›Full record

ArticlePloS one2024

Arterial floating mural thrombi are a characteristic imaging pattern in SARS-CoV-2-related ischemic stroke.

Keshet Pardo, Omer Harnof, Rani Barnea, Jonathan Naftali, Gilad Kenan, Eithan Auriel, Shlomi Peretz

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Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Keshet PardoDepartment of Neurology, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.ORCID 0000-0001-5056-2368
Omer HarnofSackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Rani BarneaDepartment of Neurology, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.
Jonathan NaftaliDepartment of Neurology, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.
Gilad KenanSackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Eithan AurielDepartment of Neurology, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.
Shlomi PeretzSackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute ischemic stroke (AIS) is a complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed to explore neurovascular imaging patterns in patients with SARS-CoV-2-related AIS.

methodsWe retrospectively analyzed clinical and radiological data of patients hospitalized with AIS and a positive PCR test for SARS-CoV-2 prior to AIS onset. The control group comprised of AIS patients from a pre-COVID-19 pandemic period matched for gender and age.

resultsThirty-five SARS-CoV-2-related stroke patients, and 35 controls were included. Fifty-seven percent of SARS-CoV-2 patients had either mild or asymptomatic disease. A distinctive imaging pattern of floating arterial mural thrombus was detected in 5 patients of the SARS-CoV-2 group. In 4 patients thrombus was attached to a stenotic atherosclerotic plaque in the proximal internal carotid artery. In the 5th patient a cardiac CTA showed multiple floating thrombi in the descending aorta. In the control group, floating thrombus was only detected in one patient. Treatment with dual antiplatelet therapy was associated with thrombus dissolution and good clinical outcome. Patients with floating thrombi had a longer time from SARS-CoV-2 diagnosis to stroke onset (mean 7.4 versus 3.4 days).

conclusionsFloating arterial mural thrombi attached to atherosclerotic plaques are unique characteristic source of AIS in SARS-CoV-2 patients. They may lead to ischemic stroke in patients with mild or asymptomatic infection up to 1-2 weeks from SARS-CoV-2 diagnosis. Patients with embolic AIS and SARS-CoV-2 diagnosis should perform high resolution cranio-cervical vascular imaging to evaluate floating thrombi as a potential embolic source.

Indexed as

COVID-19Ischemic StrokeSARS-CoV-2ThrombosisAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective Studies

Identifiers

PMID39453913
PMCPMC11508162

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.