Evidence map›Paper›PMID 39453865›Full record

ArticleACS nano2024

Mitochondrial Bioenergetics of Functional Wound Closure is Dependent on Macrophage-Keratinocyte Exosomal Crosstalk.

Anu Sharma, Rajneesh Srivastava, Surya C Gnyawali, Pramod Bhasme, Adam J Anthony, Yi Xuan, Jonathan C Trinidad, Chandan K Sen, David E Clemmer, Sashwati Roy and 1 more

Abstract read
In one paragraph

Article in ACS nano, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Mapping GlycoRNAs on an Exosomal Surface.Journal of the American Chemical Society · 2026
    Article
  6. Review
  7. Article
  8. Exosomal peptides and proteins in wound healing and skin regeneration.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anu SharmaMcGowan Institute for Regenerative Medicine, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, United States.ORCID 0000-0002-8661-1165
Rajneesh SrivastavaMcGowan Institute for Regenerative Medicine, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, United States.
Surya C GnyawaliMcGowan Institute for Regenerative Medicine, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, United States.
Pramod BhasmeMcGowan Institute for Regenerative Medicine, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, United States.
Adam J AnthonyDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
Yi XuanMcGowan Institute for Regenerative Medicine, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, United States.
Jonathan C TrinidadDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.ORCID 0000-0002-8279-1509
Chandan K SenMcGowan Institute for Regenerative Medicine, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, United States.
David E ClemmerDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.ORCID 0000-0003-4039-1360
Sashwati RoyMcGowan Institute for Regenerative Medicine, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, United States.

Funding

Exosomes in wound healingR01DK129592 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Subhadip Ghatak · 2023 to 2026
$1.7M
Tissue reprogramming in diabetic wound healingR01DK128845 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROY, SASHWATI, SEN, CHANDAN K · 2021 to 2023
$1.5M
Nanofabricated Devices and Nanomedicine Approaches for Wound HealingK25GM143572 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XUAN, YI · 2021 to 2024
$624k
NIDDK NIH HHS R01 DK128845NIDDK NIH HHS R01 DK129592NIGMS NIH HHS K25 GM143572
6 · The paper itself

Abstract

Tissue nanotransfection (TNT)-based fluorescent labeling of cell-specific exosomes has shown that exosomes play a central role in physiological keratinocyte-macrophage (mϕ) crosstalk at the wound-site. Here, we report that during the early phase of wound reepithelialization, macrophage-derived exosomes (Exo

Indexed as

Energy MetabolismExosomesKeratinocytesMacrophagesMitochondriaWound HealingAnimalsHumansMiceMice, Inbred C57BLMitochondrial Precursor Protein Import Complex ProteinsMitochondrial Precursor Protein Import Complex Proteins“don’t eat me” plasmidfunctional wound closurekeratinocyte migrationmacrophage-derived exosomesmacrophage–keratinocyte crosstalktissue nanotransfectionTOMM70

Identifiers

PMID39453865
PMCPMC11544725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.