Evidence map›Paper›PMID 39453595›Full record

ArticleBiological trace element research2025

Lead Toxicity and Maternal Exposure: Characterisation of Alveolar Bone Changes on Offspring Rats.

Matheus Ferreira Lima Rodrigues, Deiweson Souza-Monteiro, Rayssa Maitê Farias Nazário, Walessa Alana Bragança Aragão, Victória Santos Chemelo, Luciana Eiró-Quirino, Leonardo Oliveira Bittencourt, Fabrício Mezzomo Collares, Raquel Fernanda Gerlach, Sofia Pessanha and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Matheus Ferreira Lima Rodrigues *Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 01 Augusto Corrêa Street, Guamá, Belém, PA, Zip Code 66075-110, Brazil.ORCID http://orcid.org/0009-0001-2611-5493
Deiweson Souza-Monteiro *Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 01 Augusto Corrêa Street, Guamá, Belém, PA, Zip Code 66075-110, Brazil.ORCID http://orcid.org/0000-0003-1843-4184
Rayssa Maitê Farias NazárioLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 01 Augusto Corrêa Street, Guamá, Belém, PA, Zip Code 66075-110, Brazil.ORCID http://orcid.org/0009-0005-8119-746X
Walessa Alana Bragança AragãoLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 01 Augusto Corrêa Street, Guamá, Belém, PA, Zip Code 66075-110, Brazil.ORCID http://orcid.org/0000-0001-5424-9184
Victória Santos ChemeloLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 01 Augusto Corrêa Street, Guamá, Belém, PA, Zip Code 66075-110, Brazil.ORCID http://orcid.org/0000-0002-2548-2240
Luciana Eiró-QuirinoLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 01 Augusto Corrêa Street, Guamá, Belém, PA, Zip Code 66075-110, Brazil.ORCID http://orcid.org/0000-0002-8771-9784
Leonardo Oliveira BittencourtLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 01 Augusto Corrêa Street, Guamá, Belém, PA, Zip Code 66075-110, Brazil.ORCID http://orcid.org/0000-0002-9525-2723
Fabrício Mezzomo CollaresDepartment of Dental Materials, School of Dentistry, Federal University of Rio Grande Do Sul, Porto Alegre, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0002-1382-0150
Raquel Fernanda GerlachDepartment of Basic and Oral Biology, Faculty of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.ORCID http://orcid.org/0000-0002-7031-2128
Sofia PessanhaLaboratory of Instrumentation Biomedical Engineering and Radiation Physics, NOVA School of Sciences and Technology, LA-REAL, Campus Caparica, 2829-516, Caparica, Portugal.ORCID http://orcid.org/0000-0002-6039-2494
Rafael Rodrigues LimaLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 01 Augusto Corrêa Street, Guamá, Belém, PA, Zip Code 66075-110, Brazil. rafalima@ufpa.br.ORCID http://orcid.org/0000-0003-1486-4013

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lead poisoning is a global public health concern. Maternal exposure during intrauterine and lactational periods can present a higher susceptibility of harm to the offspring. Thus, pregnant female Wistar rats (Rattus norvegicus) were randomly divided in two experimental groups: control group and Lead group. The animals were exposed to 50 mg/kg of Lead Acetate daily for 42 days (21 days of gestational period + 21 days of lactational period). After the exposure period, the mandibles of the offspring were collected for lead quantification, Raman spectroscopy analysis, micro-CT, morphometric e histochemical analysis. Lead exposure altered the physical-chemical composition of alveolar bone and caused histological damage associated with a reduction in osteocyte density and collagen area fraction, increase in collagen maturity, as well as a reduction in bone volume fraction. An increase in trabecular spaces with anatomical compromise of the vertical dimensions of the bone was observed. Thus, the results suggest that developing alveolar bone is susceptible to toxic effects of lead when organisms are exposed during intrauterine and lactation periods.

Indexed as

Alveolar ProcessLeadMaternal ExposurePrenatal Exposure Delayed EffectsAnimalsFemaleMandiblePregnancyRatsRats, WistarX-Ray MicrotomographyLeadAlveolar boneLeadMicro-CTOffspringPicroSirius RedRaman Spectroscopy

Identifiers

PMID39453595

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.