Evidence map›Paper›PMID 39453559›Full record

ArticleActa neurologica Belgica2024

Regional cerebral blood flow in behavioral variant of FTD: hypoperfusion patterns and clinical associations.

Eleni Konstantinopoulou, Eleni Aretouli, Chrissa Sioka, Eleni Douli, Petros Petrikis, Ioannis Iakovou, Panagiotis Ioannidis

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Article in Acta neurologica Belgica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Eleni KonstantinopoulouSchool of Psychology and 2nd Department of Neurology, Aristotle University of Thessaloniki, Thessaloníki, Greece. elinappg@yahoo.gr.ORCID http://orcid.org/0000-0001-5771-7836
Eleni AretouliPsychology Department, University of Ioannina, Ioannina, Greece.
Chrissa SiokaLaboratory of Nuclear Medicine, School of Medicine, University of Ioannina, Ioannina, Greece.
Eleni DouliSchool of Psychology, Aristotle University of Thessaloniki, Thessaloníki, Greece.
Petros PetrikisDepartment of Psychiatry, School of Medicine, University of Ioannina, Ioannina, Greece.
Ioannis IakovouLaboratory of Nuclear Medicine, School of Medicine, Aristotle University of Thessaloniki, Thessaloníki, Greece.
Panagiotis Ioannidis2nd Department of Neurology, School of Medicine, Aristotle University of Thessaloniki, Thessaloníki, Greece.

Funding

Research Committee of Aristotle University of Thessaloniki 50177/602657
6 · The paper itself

Abstract

backgroundFindings from functional neuroimaging techniques, such as single-photon emission computed tomography (SPECT), may add useful evidence improving Frontotemporal Dementia (FTD) diagnosis. The aim of the present study was to investigate patterns of hypoperfusion in a group of patients diagnosed with the behavioral variant of FTD (bvFTD) and to explore the relationship between brain perfusion and clinical characteristics. MATERIALS AND

methodsBrain perfusion of 23 bvFTD patients was measured with SPECT scintigraphy in lobes and Brodmann areas (BAs) and the NeurogamTM software was used for image analysis. To assess behavioral disturbances and dementia severity, patients' informants completed the Frontotempotal Behavioral Inventory and the Frontotemporal Dementia Rating Scale. Descriptive statistics were used for the detection of pathological hypoperfusion in lobes and selected BAs. Associations among patients' clinical characteristics and perfusion in lobes were explored via non-parametric correlations.

resultsParticipants presented pathological hypoperfusion in frontal, limbic and temporal lobes. The most prominent deficit was observed in limbic lobes, where all participants showed pathological hypoperfusion. Decreased perfusion was also observed in limbic, frontal and temporal BAs. Perfusion in the left and right frontal lobe was associated with behavioral disturbances and disease severity, which was also correlated with perfusion in right limbic, left and right temporal areas.

conclusionPatterns of limbic, frontal and temporal hypopefusion were reported in the present study, along with associations between brain perfusion, behavioral disturbance and severity of dementia. Perfusion patterns can help to understand further associated brain biomarkers, contributing to early diagnosis and intervention in bvFTD.

Indexed as

Cerebrovascular CirculationFrontotemporal DementiaTomography, Emission-Computed, Single-PhotonAgedBrainFemaleHumansMaleMiddle AgedBehavioral disturbanceBehavioral variant,Disease severityFrontotemporal dementia,Regional cerebral blood flowSPECT

Identifiers

PMID39453559

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