Trial reportIntensive care medicine2024
Spontaneous breathing trials should be adapted for each patient according to the critical illness. A new individualised approach: the GLOBAL WEAN study.
Trial report in Intensive care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04222569 (Determination of the Optimal Spontaneous Breathing Trial During Weaning of Mechanical Ventilation), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Determination of the Optimal Spontaneous Breathing Trial During Weaning of Mechanical Ventilation: a Randomized and Personalized Cross Over Physiologic Study in the Perioperative and Critically Ill Patient
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparative effectiveness of inspiratory muscle training approaches within intensive care unit-acquired weakness prevention and rehabilitation strategies: a systematic review and component network meta-analysis.BMC pulmonary medicine · 2026Pooled it
- Melatonin and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials.Intensive care medicine · 2025Pooled it
- Physiological comparison of high-flow oxygen via endotracheal tube and T-piece strategies during spontaneous breathing trials: a randomized crossover study.Critical care (London, England) · 2026Trial
- Beyond similar inspiratory effort: interpreting tracheal high-flow during spontaneous breathing trials.Critical care (London, England) · 2026Article
- ARDS management in trauma patients.Intensive care medicine · 2026Review
- Prophylactic NIV after extubation in non-hypercapnic high-risk patients: moving beyond convenience toward clinical benefit.Intensive care medicine · 2026Article
- Update on acute respiratory failure.Intensive care medicine · 2026Article
- Rethinking extubation readiness in the neurocritical patient: from respiratory load to airway protection.Intensive care medicine · 2026Article
- Management of refractory status asthmaticus with sevoflurane in the intensive care unit: Case reports.Respiratory medicine case reports · 2026Article
- Are King's College and Clichy-Villejuif criteria used for liver transplantation still appropriate? A retrospective study over a 25-year period.Annals of intensive care · 2026Article
- Is Measurement of Inspiratory Effort and Respiratory Mechanics before Ventilator Weaning a Step toward Personalized Medicine?American journal of respiratory and critical care medicine · 2025Article
- Physiological comparison of noninvasive ventilation and CPAP on inspiratory efforts after extubation in critically ill patients with morbid obesity: a post-hoc analysis.Annals of intensive care · 2025Article
- Bench evaluation of six non-invasive ventilation home ventilators: comparison with an ICU ventilator and unsupervised clustering.BMJ open respiratory research · 2025Article
- Article
- Comparative evaluation of spontaneous breathing trial techniques for ventilator weaning: a bench study.Intensive care medicine experimental · 2025Article
- How should spontaneous breathing trials be performed in the light of recent literature?Annals of intensive care · 2025Article
- Anticoagulation management and outcomes in critically ill patients with acute mesenteric ischemia: an international study.Intensive care medicine · 2025Article
- Optimizing ICU weaning: globalizing personalized weaning strategies-author's reply.Intensive care medicine · 2025Article
- Optimizing ICU weaning: globalizing personalized weaning strategies.Intensive care medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSpontaneous breathing trials (SBT) evaluate the patient's capacity to maintain inspiratory effort after extubation. SBT practices are heterogeneous and not individualised. The objective of this study was to assess which SBT best reproduces inspiratory effort after extubation in five critical illnesses.
methodsIn this multicentre randomized cross-over study, adult intensive care unit patients under invasive mechanical ventilation for at least 24-h and ready for extubation, underwent three 15-min SBTs in random order: pressure support ventilation level of 7-cmH
resultsFive hundred measures of effort from 100 patients were analysed. PTPmin (cmH
conclusionUnassisted SBTs, namely PSV0PEEP0 and T-piece trial, are the most appropriate to replicate the postextubation effort to breathe.
Indexed as
Identifiers
39453494What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.