Evidence map›Paper›PMID 39453430›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2024

Human sympathetic neuronal discharge and recruitment patterns regulate neuropeptide Y bioavailability.

Stephen A Klassen, Jacqueline K Limberg, Ronée E Harvey, Chad C Wiggins, Julia E Spafford, Nathaniel J Iannarelli, Jonathon W Senefeld, Wayne T Nicholson, Timothy B Curry, Michael J Joyner and 2 more

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. The role of αAmerican journal of physiology. Heart and circulatory physiology · 2025
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Stephen A KlassenDepartment of Kinesiology, Brock University, St. Catharines, Ontario, Canada.ORCID 0000-0002-4560-8728
Jacqueline K LimbergDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.ORCID 0000-0001-9982-5851
Ronée E HarveyDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-8861-5477
Chad C WigginsDepartment of Kinesiology, Michigan State University, East Lansing, Michigan, United States.ORCID 0000-0002-6458-0142
Julia E SpaffordDepartment of Kinesiology, Brock University, St. Catharines, Ontario, Canada.
Nathaniel J IannarelliDepartment of Kinesiology, Brock University, St. Catharines, Ontario, Canada.
Jonathon W SenefeldDepartment of Health and Kinesiology, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States.ORCID 0000-0001-8116-3538
Wayne T NicholsonDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Timothy B CurryDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Michael J JoynerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-7135-7643
J Kevin ShoemakerSchool of Kinesiology, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.ORCID 0000-0002-6794-5979
Sarah E BakerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0001-9647-7660

Funding

DIABETES AND METABOLISMT32DK007352 · NIDDK · MAYO CLINIC ROCHESTER · PI MICHAEL D. JENSEN · 1986 to 2026
$9.4M
Variant Hemoglobin and Cardiorespiratory Regulation in HumansR35HL139854 · NHLBI · MAYO CLINIC ROCHESTER · PI JOYNER, MICHAEL J · 2018 to 2024
$5.8M
Hot Flashes and Neurovascular Function in WomenK01HL148144 · NHLBI · MAYO CLINIC ROCHESTER · PI BAKER, SARAH ELIZABETH · 2021 to 2025
$867k
Reflex responses to intermittent hypoxia in humans: Mechanisms and consequencesR00HL130339 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI LIMBERG, JACQUELINE K · 2017 to 2019
$729k
Skeletal muscle performance and cellular adaptations to high hemoglobin-oxygen affinityF32HL154320 · NHLBI · MAYO CLINIC ROCHESTER · PI SENEFELD, JONATHON · 2020 to 2021
$117k
Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC) 05293HHS | National Institutes of Health (NIH) K01-HL-148144HHS | National Institutes of Health (NIH) R-35-HL-139854NHLBI NIH HHS F32 HL154320NHLBI NIH HHS K01 HL148144NHLBI NIH HHS R00 HL130339NHLBI NIH HHS R35 HL139854NIDDK NIH HHS T32 DK007352
6 · The paper itself

Abstract

What is the purpose of sympathetic neuronal action potential (AP) discharge and recruitment patterns for human vascular regulation? This study tested the hypothesis that sympathetic neuronal discharge and recruitment patterns regulate neuropeptide Y (NPY) bioavailability. We used microneurography to record muscle sympathetic nerve activity and a continuous wavelet transform to detect sympathetic APs during a baseline condition and intravenous dexmedetomidine infusion (α

Indexed as

Action PotentialsDexmedetomidineNeuropeptide YNorepinephrineSympathetic Nervous SystemAdrenergic alpha-2 Receptor AgonistsAdultArterial PressureBiological AvailabilityFemaleHumansInfusions, IntravenousMaleMuscle, SkeletalRecruitment, NeurophysiologicalYoung AdultAdrenergic alpha-2 Receptor AgonistsDexmedetomidineNeuropeptide YNorepinephrineaction potentialblood pressuremicroneurographyneurotransmittersympathetic nervous system

Identifiers

PMID39453430
PMCPMC11684957

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.