Evidence map›Paper›PMID 39453218›Full record

ArticleToxins2024

Dysphagia and Muscle Weakness Secondary to Botulinum Toxin Type A Treatment of Cervical Dystonia: A Drug Class Analysis of Prescribing Information.

Khashayar Dashtipour, Han S Lee, Aaron Ellenbogen, Rashid Kazerooni, Todd M Gross, David A Hollander, Conor J Gallagher

Abstract read
In one paragraph

Article in Toxins, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Observational
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Khashayar DashtipourDepartment of Neurology/Movement Disorders, Loma Linda University, Loma Linda, CA 92354, USA.
Han S LeeDepartment of Neurology, The Permanente Medical Group, Greater Southern Alameda Area-San Leandro/Fremont, San Leandro, CA 94577, USA.ORCID 0009-0007-6508-2640
Aaron EllenbogenQuest Research Institute, Farmington Hills, MI 48334, USA.
Rashid KazerooniRevance Therapeutics, Nashville, TN 37203, USA.ORCID 0000-0003-3223-2597
Todd M GrossRevance Therapeutics, Nashville, TN 37203, USA.ORCID 0000-0001-5482-5313
David A HollanderRevance Therapeutics, Nashville, TN 37203, USA.
Conor J GallagherRevance Therapeutics, Nashville, TN 37203, USA.ORCID 0000-0002-5488-6594

Funding

Revance Therapeutics Revance Therapeutics
6 · The paper itself

Abstract

The first-line management of cervical dystonia (CD) symptoms is intramuscular injection of botulinum toxin type A (BoNTA). However, a comparison of safety among BoNTAs is difficult because, per regulatory authorities, units of BoNTA activity are not interchangeable. Dysphagia and muscle weakness are widely considered two key adverse events to monitor closely in the treatment of CD. This integrated analysis compared the safety of BoNTAs approved for CD in the US by evaluating relationships between the incidence of dysphagia and muscle weakness in prescribing information and the core neurotoxin content. Coefficients The coefficients of determination (R

Indexed as

Botulinum Toxins, Type ADeglutition DisordersMuscle WeaknessNeuromuscular AgentsTorticollisHumansBotulinum Toxins, Type ANeuromuscular Agentsbotulinum toxinscervical dystoniadysphagiadystonic disordersmovement disordersmuscle weaknessneuromodulatorpeptidestype A

Identifiers

PMID39453218
PMCPMC11510929

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.