Evidence map›Paper›PMID 39453206›Full record

ArticleToxins2024

From Venom to Vein: Factor VII Activation as a Major Pathophysiological Target for Procoagulant Australian Elapid Snake Venoms.

Uthpala Chandrasekara, Abhinandan Chowdhury, Lorenzo Seneci, Christina N Zdenek, Nathan Dunstan, Bryan G Fry

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Uthpala ChandrasekaraAdaptive Biotoxicology Lab, School of the Environment, University of Queensland, St. Lucia, QLD 4072, Australia.
Abhinandan ChowdhuryAdaptive Biotoxicology Lab, School of the Environment, University of Queensland, St. Lucia, QLD 4072, Australia.
Lorenzo SeneciAdaptive Biotoxicology Lab, School of the Environment, University of Queensland, St. Lucia, QLD 4072, Australia.
Christina N ZdenekSchool of the Environment, University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0002-0385-500X
Nathan DunstanVenom Supplies Pty Ltd., Stonewell Rd., Tanunda, SA 5352, Australia.ORCID 0000-0002-9707-7631
Bryan G FryAdaptive Biotoxicology Lab, School of the Environment, University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0001-6661-1283

Funding

Australian Research Council DP190100304
6 · The paper itself

Abstract

Australian elapid snake venoms are uniquely procoagulant, utilizing blood clotting enzyme Factor Xa (FXa) as a toxin, which evolved as a basal trait in this clade. The subsequent recruitment of Factor Va (FVa) as a toxin occurred in the last common ancestor of taipans (

Indexed as

Blood CoagulationElapidaeElapid VenomsFactor VIIProthrombinAnimalsAustraliaFactor VaFactor XaHumansElapid VenomsFactor VaFactor VIIFactor XaProthrombinadaptationcoagulationevolutionary biologyFactor VaFactor VIImolecular evolutionprothrombinvenomzymogen

Identifiers

PMID39453206
PMCPMC11510989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.