Evidence map›Paper›PMID 39453170›Full record

ArticleToxics2024

Prediction of Dynamic Toxicity of Nanoparticles Using Machine Learning.

Ivan Khokhlov, Leonid Legashev, Irina Bolodurina, Alexander Shukhman, Daniil Shoshin, Svetlana Kolesnik

Abstract read
In one paragraph

Article in Toxics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
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  5. Article
  6. Review
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  9. Article
  10. Review
  11. AI-based nanotoxicity data extraction and prediction of nanotoxicity.Computational and structural biotechnology journal · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ivan KhokhlovResearch Institute of Digital Intelligent Technologies, Orenburg State University, Pobedy Pr. 13, Orenburg 460018, Russia.
Leonid LegashevResearch Institute of Digital Intelligent Technologies, Orenburg State University, Pobedy Pr. 13, Orenburg 460018, Russia.ORCID 0000-0001-6351-404X
Irina BolodurinaResearch Institute of Digital Intelligent Technologies, Orenburg State University, Pobedy Pr. 13, Orenburg 460018, Russia.
Alexander ShukhmanResearch Institute of Digital Intelligent Technologies, Orenburg State University, Pobedy Pr. 13, Orenburg 460018, Russia.ORCID 0000-0003-2061-9102
Daniil ShoshinFederal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, Orenburg 460000, Russia.ORCID 0000-0003-3086-681X
Svetlana KolesnikResearch Institute of Digital Intelligent Technologies, Orenburg State University, Pobedy Pr. 13, Orenburg 460018, Russia.ORCID 0009-0009-3008-0308

Funding

Russian Ministry of Science and Higher Education 075-15-2024-550
6 · The paper itself

Abstract

Predicting the toxicity of nanoparticles plays an important role in biomedical nanotechnologies, in particular in the creation of new drugs. Safety analysis of nanoparticles can identify potentially harmful effects on living organisms and the environment. Advanced machine learning models are used to predict the toxicity of nanoparticles in a nutrient solution. In this article, we performed a comparative analysis of the current state of research in the field of nanoparticle toxicity analysis using machine learning methods; we trained a regression model for predicting the quantitative toxicity of nanoparticles depending on their concentration in the nutrient solution at a fixed point in time with the achieved metrics values of MSE = 2.19 and RMSE = 1.48; we trained a multi-class classification model for predicting the toxicity class of nanoparticles depending on their concentration in the nutrient solution at a fixed point in time with the achieved metrics values of Accuracy = 0.9756, Recall = 0.9623, F1-Score = 0.9640, and Log Loss = 0.1855. As a result of the analysis, we concluded the good predictive ability of the trained models. The optimal dosages for the nanoparticles under study were determined as follows: ZnO = 9.5 × 10

Indexed as

artificial intelligencenanoparticlespredictiontoxicity

Identifiers

PMID39453170
PMCPMC11511391

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.