Evidence map›Paper›PMID 39453163›Full record

ArticleToxics2024

Regarding Bioanalysis Lasting a Few Minutes: Automated Cooling-SPME and Fast-GC for Urinary 2-Phenyl-2-Propanol Monitoring.

Stefano Dugheri, Niccolò Fanfani, Giovanni Cappelli, Antonio Marigliano, Elisabetta Bucaletti, Donato Squillaci, Ilaria Rapi, Lorenzo Venturini, Giulia Pizzella, Sara Manetta and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Stefano DugheriDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50121 Florence, Italy.
Niccolò FanfaniDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50121 Florence, Italy.
Giovanni CappelliDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50121 Florence, Italy.ORCID 0000-0002-5623-1671
Antonio MariglianoDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50121 Florence, Italy.
Elisabetta BucalettiDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50121 Florence, Italy.ORCID 0000-0003-2060-5392
Donato SquillaciDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50121 Florence, Italy.ORCID 0000-0001-8665-845X
Ilaria RapiDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50121 Florence, Italy.
Lorenzo VenturiniDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50121 Florence, Italy.ORCID 0009-0008-3804-9607
Giulia PizzellaEni Health, Safety, Environment & Quality EE, Via Ribotta 51, 00144 Rome, Italy.
Sara ManettaEni Health, Safety, Environment & Quality EE, Via Ribotta 51, 00144 Rome, Italy.
Alfonso PavoneEni Health, Safety, Environment & Quality EE, Via Ribotta 51, 00144 Rome, Italy.
Michele SecchiEni Energy Evolution, REVT Livorno Refinery, Via Aurelia 7, 57017 Collesalvetti, Italy.
Iacopo RainaldiEni Energy Evolution, REVT Livorno Refinery, Via Aurelia 7, 57017 Collesalvetti, Italy.
Nicola MucciDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50121 Florence, Italy.ORCID 0000-0003-0579-1035

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An innovative SPME head space GC-MS method, in cooling mode, using a fully automated routine, was developed to detect 2-phenyl-2-propanol, a representative urinary metabolite of cumene. Following an acid hydrolysis and derivatization step with lowered quantities of reagents, acetic anhydride and pyridine, a 30 μm polydimethylsiloxane SPME fiber was used to sample derivatized 2-phenyl-2-propanol, such as benzenemethanol,α,α-dimethyl-acetate, from the headspace. Performances of the method, optimized through experimental design, provide an LOD of 0.034 mg/L and an LOQ 0.10 mg/L, with a short sampling time necessary per sample. The method, developed on standard solutions, will be applied to both occupationally exposed and non-exposed populations.

Indexed as

2-phenyl-2-propanolcooling SPMEcumenederivatizationfull automationGC–MSSPME

Identifiers

PMID39453163
PMCPMC11511570

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.