Evidence map›Paper›PMID 39452864›Full record

ArticleMarine drugs2024

Potential of Marine Sponge Metabolites against Prions: Bromotyrosine Derivatives, a Family of Interest.

Maha Sinane, Colin Grunberger, Lucile Gentile, Céline Moriou, Victorien Chaker, Pierre Coutrot, Alain Guenneguez, Marie-Aude Poullaouec, Solène Connan, Valérie Stiger-Pouvreau and 7 more

Abstract read
In one paragraph

Article in Marine drugs, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Marine natural products.Natural product reports · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Maha SinaneUniv Brest, Inserm, EFS, UMR 1078, GGB, School of Medicine, F-29200 Brest, France.
Colin GrunbergerIRD, CNRS, Ifremer, Univ Brest, LEMAR, IUEM, F-29280 Plouzane, France.
Lucile GentileUniv Brest, Inserm, EFS, UMR 1078, GGB, School of Medicine, F-29200 Brest, France.ORCID 0000-0001-5415-9584
Céline MoriouCNRS, Institut de Chimie des Substances Naturelles, Université Paris-Saclay, F-91190 Gif-sur-Yvette, France.ORCID 0000-0003-2481-6461
Victorien ChakerUniv Brest, Inserm, EFS, UMR 1078, GGB, School of Medicine, F-29200 Brest, France.
Pierre CoutrotUniv Brest, Inserm, EFS, UMR 1078, GGB, School of Medicine, F-29200 Brest, France.
Alain GuenneguezIRD, CNRS, Ifremer, Univ Brest, LEMAR, IUEM, F-29280 Plouzane, France.
Marie-Aude PoullaouecIRD, CNRS, Ifremer, Univ Brest, LEMAR, IUEM, F-29280 Plouzane, France.
Solène ConnanIRD, CNRS, Ifremer, Univ Brest, LEMAR, IUEM, F-29280 Plouzane, France.ORCID 0000-0002-8280-1041
Valérie Stiger-PouvreauIRD, CNRS, Ifremer, Univ Brest, LEMAR, IUEM, F-29280 Plouzane, France.ORCID 0000-0003-3041-0468
Mayalen ZubiaUPF, Ifremer, ILM, IRD, UMR 241 SECOPOL, BP6570, 98702 Faa'a, Tahiti, French Polynesia.
Yannick FleuryUniv Brest, Univ Bretagne Sud, CNRS, LBCM, EMR 6076, F-29000 Quimper, France.ORCID 0000-0002-1638-0963
Stéphane CérantolaUniv Brest, Plateforme RMN-RPE, F-29238 Brest, France.
Nelly KervarecUniv Brest, Plateforme Spectrométrie de Masse, F-29238 Brest, France.
Ali Al-MourabitCNRS, Institut de Chimie des Substances Naturelles, Université Paris-Saclay, F-91190 Gif-sur-Yvette, France.ORCID 0000-0002-1762-6910
Sylvain PetekIRD, CNRS, Ifremer, Univ Brest, LEMAR, IUEM, F-29280 Plouzane, France.ORCID 0000-0001-7920-0467
Cécile VoissetUniv Brest, Inserm, EFS, UMR 1078, GGB, School of Medicine, F-29200 Brest, France.ORCID 0000-0001-7505-1927

Funding

Centre National de la Recherche Scientifique ICSNComité d'entente et de coordination des associations de Parkinsoniens (CECAP) GGB Laboratory (UMR1078) - Group PRiMEFlotte Océanographique Française Wallis 2018 cruiseInserm Grand Ouest GGB Laboratory (UMR1078)Institut Brestois Santé Agro Matière - Univ Brest Proteomar projectInstitut de Recherche pour le Développement Colin Grunberger Master 1 and Master 2 thesisInstitut de Recherche pour le Développement LEMAR (UMR6539)Institut de Recherche pour le Développement Wallis 2018 cruiseInstitut Universitaire Européen de la Mer - Univ Brest Proteomar projectLabex Mer Wallis 2018 cruiseMinistère de l'enseignement supérieur et de la recherche Lucile Gentile PhD thesisMinistère de l'enseignement supérieur et de la recherche Maha Sinane PhD thesisMuseum National d'Histoire Naturelle Wallis 2018 cruiseNRJ-Institut de France GGB Laboratory (UMR1078) - Group PRiMEWallis and Futuna Environment Service Wallis 2018 cruise
6 · The paper itself

Abstract

The screening of 166 extracts from tropical marine organisms (invertebrates, macroalgae) and 3 cyclolipopeptides from microorganisms against yeast prions highlighted the potential of Verongiida sponges to prevent the propagation of prions. We isolated the known compounds purealidin Q (

Indexed as

PoriferaPrionsTyrosineAnimalsAquatic OrganismsHumansMicePrPSc ProteinsbromotyrosinePrionsPrPSc ProteinsTyrosinebromotyrosine derivativesER stressmarine spongesprion diseasesPrPScSuberea labouteiVerongiidayeast-based screening

Identifiers

PMID39452864
PMCPMC11509309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.