Evidence map›Paper›PMID 39452740›Full record

ArticlePathogens (Basel, Switzerland)2024

Transcriptomic and Proteomic Insights into Host Immune Responses in Pediatric Severe Malarial Anemia: Dysregulation in HSP60-70-TLR2/4 Signaling and Altered Glutamine Metabolism.

Clinton O Onyango, Samuel B Anyona, Ivy Hurwitz, Evans Raballah, Sharely A Wasena, Shamim W Osata, Philip Seidenberg, Benjamin H McMahon, Christophe G Lambert, Kristan A Schneider and 3 more

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Chaperonin in health and disease.Molecular biomedicine · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Clinton O OnyangoDepartment of Biomedical Sciences and Technology, School of Public Health and Community Development, Maseno University, Maseno 40100, Kenya.ORCID 0000-0002-4197-5336
Samuel B AnyonaKenya Global Health Programs, University of New Mexico, Kisumu and Siaya 40100, Kenya.ORCID 0000-0001-5813-4018
Ivy HurwitzCenter for Global Health, Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA.ORCID 0000-0003-1566-1111
Evans RaballahKenya Global Health Programs, University of New Mexico, Kisumu and Siaya 40100, Kenya.ORCID 0000-0002-3304-6836
Sharely A WasenaDepartment of Biomedical Sciences and Technology, School of Public Health and Community Development, Maseno University, Maseno 40100, Kenya.ORCID 0000-0002-6462-3712
Shamim W OsataDepartment of Biomedical Sciences and Technology, School of Public Health and Community Development, Maseno University, Maseno 40100, Kenya.ORCID 0000-0002-1067-2818
Philip SeidenbergCenter for Global Health, Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
Benjamin H McMahonCenter for Global Health, Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
Christophe G LambertCenter for Global Health, Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA.ORCID 0000-0003-1994-2893
Kristan A SchneiderCenter for Global Health, Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA.ORCID 0000-0003-4138-1180
Collins OumaDepartment of Biomedical Sciences and Technology, School of Public Health and Community Development, Maseno University, Maseno 40100, Kenya.
Qiuying ChengCenter for Global Health, Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA.ORCID 0000-0002-1343-1171
Douglas J PerkinsCenter for Global Health, Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA.ORCID 0000-0001-9390-6255

Funding

Partnership for Global Health Research Training Program (Renewal)-Supplement for OBSSR, NCI, NCI-AIDS and NIDCDD43TW010543 · FIC · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Wafaie W Fawzi, DAVIDSON HOWES HAMER · 2017 to 2026
$12.1M
Harnessing the Malarial Immunity Omics Landscape in Vaccinated and Unvaccinated Children for Improved Therapeutic StrategiesR01AI130473 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Samuel Bonuke Anyona, Douglas Jay Perkins · 2018 to 2026
$5.6M
TRAINING AND RESEARCH ON SEVERE MALARIAL ANEMIAD43TW005884 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Collins Ouma, Douglas Jay Perkins · 2002 to 2026
$5.2M
GENETIC BASIS OF SEVERE MALARIAL ANEMIAR01AI051305 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PERKINS, DOUGLAS JAY · 2002 to 2011
$4.7M
Dysregulation of the Human Ubiquitin Proteasome System in Pediatric Severe Malarial AnemiaK43TW011581 · FIC · MASENO UNIVERSITY · PI ANYONA, SAMUEL BONUKE · 2020 to 2023
$280k
FIC NIH HHS D43 TW005884FIC NIH HHS D43 TW010543FIC NIH HHS K43 TW011581NIAID NIH HHS R01 AI051305NIAID NIH HHS R01 AI130473NIH HHS 1C06TW058841-24S26NIH HHS R01AI130473
6 · The paper itself

Abstract

Severe malarial anemia (SMA, Hb < 6.0 g/dL) is a leading cause of childhood morbidity and mortality in holoendemic

Indexed as

AnemiaGlutamineMalaria, FalciparumProteomicsSignal TransductionToll-Like Receptor 2Toll-Like Receptor 4TranscriptomeChaperonin 60ChildChild, PreschoolFemaleHSP70 Heat-Shock ProteinsHumansInfantKenyaChaperonin 60GlutamineHSP70 Heat-Shock ProteinsHSPD1 protein, humanMitochondrial ProteinsTLR2 protein, humanTLR4 protein, humanToll-Like Receptor 2Toll-Like Receptor 4childhood innate immunitydifferential gene expressionglutamine synthetaseglutamine transportersheat shock proteinshost immune responseproteomicsRNA-seqtoll-like receptors

Identifiers

PMID39452740
PMCPMC11510049

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.