Evidence map›Paper›PMID 39452706›Full record

ArticlePathogens (Basel, Switzerland)2024

Enhancement of ROS Production by Catechin Is a Primary Effect of Increased Azole Efficacy in

Nora Tóth Hervay, Daniel Eliaš, Lucia Černáková, Juraj Jacko, Marcela Habová, Natália Chovancová, Yvetta Gbelská

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Catechin Augments the Antifungal Efficacy of Fluconazole AgainstInternational journal of molecular sciences · 2026
    Article
  3. Natural product based approaches to overcomeFrontiers in antibiotics · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nora Tóth HervayDepartment of Microbiology and Virology, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovicova 6, 842 15 Bratislava, Slovakia.ORCID 0000-0002-2784-1032
Daniel EliašDepartment of Microbiology and Virology, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovicova 6, 842 15 Bratislava, Slovakia.ORCID 0000-0002-2913-2918
Lucia ČernákováDepartment of Microbiology and Virology, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovicova 6, 842 15 Bratislava, Slovakia.ORCID 0000-0001-5300-3254
Juraj JackoDepartment of Nuclear Physics and Biophysics, Faculty of Mathematics, Physics and Informatics, Comenius University in Bratislava, Mlynska Dolina, 842 48 Bratislava, Slovakia.
Marcela HabováDepartment of Microbiology and Virology, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovicova 6, 842 15 Bratislava, Slovakia.
Natália ChovancováDepartment of Microbiology and Virology, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovicova 6, 842 15 Bratislava, Slovakia.
Yvetta GbelskáDepartment of Microbiology and Virology, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovicova 6, 842 15 Bratislava, Slovakia.ORCID 0000-0001-7516-8463

Funding

Slovak Grant Agency of Science and The Slovak Research and Developmental Agency VEGA 1/0388/22, VEGA 1/0240/23, APVV-19-0094, APVV-21-0302
6 · The paper itself

Abstract

Fungal infections have become an important public health problem. Currently, there are only three available classes of antifungals for the treatment of invasive infections. Two of them, azoles and polyenes, target the synthesis of ergosterol or bind to sterols. A promising strategy to improve current therapies is the use of natural compounds in combinational therapies with the existing antifungals. In this work, we analyzed the changes in the susceptibility of the mutant strain of

Indexed as

Antifungal AgentsCandida glabrataCatechinReactive Oxygen SpeciesAnimalsAzolesCandidiasisDrug Resistance, FungalDrug SynergismErgosterolFluconazoleFungal ProteinsGene Expression Regulation, FungalMethyltransferasesMiconazoleMicrobial Sensitivity TestsAntifungal AgentsAzolesCatechindelta 24-sterol methyltransferaseErgosterolFluconazoleFungal ProteinsMethyltransferasesMiconazoleReactive Oxygen SpeciesCandida glabratacatechinERG6Nakaseomyces glabratusOSR

Identifiers

PMID39452706
PMCPMC11510055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.