Evidence map›Paper›PMID 39452586›Full record

ArticleJournal of functional biomaterials2024

Chemically Pretreated Densification of Juniper Wood for Potential Use in Osteosynthesis Bone Implants.

Laura Andze, Vadims Nefjodovs, Martins Andzs, Marite Skute, Juris Zoldners, Martins Kapickis, Arita Dubnika, Janis Locs, Janis Vetra

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Feature Papers in Bone Biomaterials.Journal of functional biomaterials · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laura AndzeLatvian State Institute of Wood Chemistry, Dzerbenes Street 27, LV-1006 Riga, Latvia.ORCID 0000-0001-6085-6300
Vadims NefjodovsDepartment of Morphology, Institute of Anatomy and Anthropology, Riga Stradins University, Dzirciema Street 16, LV-1007 Riga, Latvia.ORCID 0000-0002-2957-0571
Martins AndzsLatvian State Institute of Wood Chemistry, Dzerbenes Street 27, LV-1006 Riga, Latvia.
Marite SkuteLatvian State Institute of Wood Chemistry, Dzerbenes Street 27, LV-1006 Riga, Latvia.
Juris ZoldnersLatvian State Institute of Wood Chemistry, Dzerbenes Street 27, LV-1006 Riga, Latvia.
Martins KapickisMicrosurgery Centre of Latvia, Brivibas Gatve 410, LV-1024 Riga, Latvia.
Arita DubnikaInstitute of Biomaterials and Bioengineering, Faculty of Natural Science and Technology, Riga Technical University, Pulka Street 3, LV-1048 Riga, Latvia.ORCID 0000-0001-8940-5335
Janis LocsInstitute of Biomaterials and Bioengineering, Faculty of Natural Science and Technology, Riga Technical University, Pulka Street 3, LV-1048 Riga, Latvia.ORCID 0000-0003-3162-7431
Janis VetraDepartment of Morphology, Institute of Anatomy and Anthropology, Riga Stradins University, Dzirciema Street 16, LV-1007 Riga, Latvia.

Funding

European Union's Horizon 2020 research and innovation programme Grant agreement No. 857287Federation of European Societies for Surgery of the Hand FESSH Research grant 2024Latvian State Institute of Wood Chemistry HardBone" 2024, 05-24Latvian State Institute of Wood Chemistry "WoodBone" 2023, 03-23
6 · The paper itself

Abstract

The aim of the study was to perform treatment of juniper wood to obtain wood material with a density and mechanical properties comparable to bone, thus producing a potential material for use in osteosynthesis bone implants. In the first step, partial delignification of wood sample was obtained by Kraft cooking. The second step was extraction with ethanol, ethanol-water mixture, saline, and water to prevent the release of soluble compounds and increase biocompatibility. In the last step, the thermal densification at 100 °C for 24 h was implemented. The results obtained in the dry state are equivalent to the properties of bone. The swelling of chemically pre-treated densified wood was reduced compared to chemically untreated densified wood. Samples showed no cytotoxicity by in vitro cell assays. The results of the study showed that it is possible to obtain noncytotoxic wood samples with mechanical properties equivalent to bones by partial delignification, extraction, and densification. However, further research is needed to ensure the material's shape stability, water resistance, and reduced swelling.

Indexed as

chemical pretreatmentcompressed solid woodin vitrojuniper woodkraft cookingpartial delignificationwood bone implantswood densification

Identifiers

PMID39452586
PMCPMC11508927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.