Evidence map›Paper›PMID 39452580›Full record

ArticleJournal of functional biomaterials2024

Suspension-Sprayed Calcium Phosphate Coatings with Antibacterial Properties.

Maria Carolina Lanzino, Long-Quan R V Le, Anika Höppel, Andreas Killinger, Wolfgang Rheinheimer, Sofia Dembski, Ali Al-Ahmad, Hermann O Mayr, Michael Seidenstuecker

Abstract read
In one paragraph

Article in Journal of functional biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maria Carolina LanzinoInstitute for Manufacturing Technologies of Ceramic Components and Composites (IFKB), University of Stuttgart, 70569 Stuttgart, Germany.ORCID 0009-0006-2892-2404
Long-Quan R V LeG.E.R.N. Center of Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany.ORCID 0009-0009-2633-3579
Anika HöppelDepartment of Tissue Engineering and Regenerative Medicine (TERM), University Hospital Würzburg, 97070 Würzburg, Germany.ORCID 0009-0004-7968-3509
Andreas KillingerInstitute for Manufacturing Technologies of Ceramic Components and Composites (IFKB), University of Stuttgart, 70569 Stuttgart, Germany.
Wolfgang RheinheimerInstitute for Manufacturing Technologies of Ceramic Components and Composites (IFKB), University of Stuttgart, 70569 Stuttgart, Germany.
Sofia DembskiDepartment of Tissue Engineering and Regenerative Medicine (TERM), University Hospital Würzburg, 97070 Würzburg, Germany.ORCID 0000-0003-0427-1644
Ali Al-AhmadDepartment of Operative Dentistry and Periodontology, Center for Dental Medicine, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, 79106 Freiburg, Germany.ORCID 0000-0001-8769-599X
Hermann O MayrG.E.R.N. Center of Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany.ORCID 0000-0002-5100-0372
Michael SeidenstueckerG.E.R.N. Center of Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany.ORCID 0000-0001-6643-6358

Funding

Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) 240897167
6 · The paper itself

Abstract

Prosthesis loosening due to lack of osteointegration between an implant and surrounding bone tissue is one of the most common causes of implant failure. Further, bacterial contamination and biofilm formation onto implants represent a serious complication after surgery. The enhancement of osteointegration can be achieved by using bioconductive materials that promote biological responses in the body, stimulating bone growth and thus bonding to tissue. Through the incorporation of antibacterial substances in bioconductive, biodegradable calcium phosphate (CaP) coatings, faster osteointegration and bactericidal properties can be achieved. In this study, Cu-doped CaP supraparticles are spray-dried and suspension-sprayed CaP ceramic coatings with antibacterial properties are prepared using high-velocity suspension flame spraying (HVSFS). The objective was to increase the coatings' porosity and investigate which Cu-doped supraparticles have the strongest antibacterial properties when introduced into the coating layers. Biocompatibility was tested on human Osteosarcoma cells MG63. A porosity of at least 13% was achieved and the supraparticles could be implemented, enhancing it up to 16%. The results showed that the addition of Cu-doped supraparticles did not significantly reduce the number of viable cells compared to the Cu-free sample, demonstrating good biocompatibility. The antimicrobial activity was assessed against the bacterial strains

Indexed as

antimicrobial activityCaPcoatingjointsupraparticles

Identifiers

PMID39452580
PMCPMC11509040

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.