Evidence map›Paper›PMID 39452531›Full record

ArticleJournal of personalized medicine2024

Subthalamic Stimulation Improves Short-Term Satisfaction with Life and Treatment in Parkinson's Disease.

Anna Sauerbier, Pia Bachon, Leire Ambrosio, Philipp A Loehrer, Alexandra Rizos, Stefanie T Jost, Alexandra Gronostay, Gereon R Fink, Keyoumars Ashkan, Christopher Nimsky and 6 more

Abstract read
In one paragraph

Article in Journal of personalized medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Anna SauerbierUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, 50937 Cologne, Germany.
Pia BachonUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, 50937 Cologne, Germany.ORCID 0009-0002-4614-4029
Leire AmbrosioNIHR Applied Research Collaboration Wessex, School of Health Sciences, University of Southampton, Southampton SO17 1BJ, UK.
Philipp A LoehrerDepartment of Neurology, University Hospital Giessen and Marburg, Campus Marburg, 35043 Marburg, Germany.ORCID 0000-0002-5279-2156
Alexandra RizosUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, 50937 Cologne, Germany.
Stefanie T JostUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, 50937 Cologne, Germany.
Alexandra GronostayUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, 50937 Cologne, Germany.
Gereon R FinkUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, 50937 Cologne, Germany.
Keyoumars AshkanParkinson Foundation International Centre of Excellence, King's College Hospital, London SE5 8AF, UK.
Christopher NimskyDepartment of Neurosurgery, University Marburg, 35043 Marburg, Germany.ORCID 0000-0002-8216-9410
Veerle Visser-VandewalleUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Stereotactic and Functional Neurosurgery, 50937 Cologne, Germany.
K Ray ChaudhuriInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.ORCID 0000-0003-2815-0505
Lars TimmermannDepartment of Neurology, University Hospital Giessen and Marburg, Campus Marburg, 35043 Marburg, Germany.
Pablo Martinez-MartinCenter for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Carlos III Institute of Health, 28029 Madrid, Spain.ORCID 0000-0003-0837-5280
Haidar S DafsariUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, 50937 Cologne, Germany.ORCID 0000-0001-8849-4233
EUROPAR, the Non-Motor Parkinson’s Disease Research Group and the German Parkinson Society Non-Motor Symptoms Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of subthalamic stimulation (STN-DBS) on patients' personal satisfaction with life and their Parkinson's disease (PD) treatment is understudied, as is its correlation with quality of life (QoL). Therefore, we tested the hypothesis that STN-DBS for PD enhances satisfaction with life and treatment. In a prospective, multicenter study with a 6-month follow-up involving 121 patients, we measured the main outcomes using the Satisfaction with Life and Treatment Scale (SLTS-7). Secondary outcomes included the eight-item PD Questionnaire (PDQ-8), European QoL Questionnaire (EQ-5D-3L), EQ-Visual Analogue Scale (VAS), Non-Motor Symptom Scale (NMSS), Hospital Anxiety and Depression Scale (HADS), and Unified PD Rating Scale (UPDRS). Longitudinal outcome changes, effect sizes (Cohen's d), and correlations between outcome changes were analyzed. SLTS-7 scores improved at the 6-month follow-up, particularly in the domains of 'satisfaction with physical health' and 'satisfaction with treatment'. Change scores correlated strongly (EQ-VAS), moderately (PDQ-8 SI and HADS), and weakly (UPDRS-activities of daily living and EQ-5D-3L) with other scales. Satisfaction with physical health, psychosocial well-being, or treatment was not related to UPDRS-motor examination. This study provides evidence that STN-DBS enhances patients' personal satisfaction with life and treatment. This satisfaction is associated with improvements in the QoL, daily activities, and neuropsychiatric aspects of PD rather than its motor aspects.

Indexed as

deep brain stimulationlife satisfactionnon-motor symptomsquality of lifetreatment satisfaction

Identifiers

PMID39452531
PMCPMC11508541

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.