Evidence map›Paper›PMID 39452239›Full record

ArticleAntibiotics (Basel, Switzerland)2024

Guanethidine Restores Tetracycline Sensitivity in Multidrug-Resistant

Xiaoou Zhao, Mengna Zhang, Zhendu Zhang, Lei Wang, Yu Wang, Lizai Liu, Duojia Wang, Xin Zhang, Luobing Zhao, Yunhui Zhao and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Pacin, a novel bacteriocin fromMicrobiology spectrum · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaoou ZhaoCollege of Animal Science and Technology, Jilin Agricultural University, Xincheng Street No. 2888, Changchun 130118, China.ORCID 0000-0002-7323-0646
Mengna ZhangCollege of Animal Science and Technology, Jilin Agricultural University, Xincheng Street No. 2888, Changchun 130118, China.
Zhendu ZhangInstitute of Animal Husbandry and Veterinary Medicine, Jilin Academy of Agricultural Science, Kemao Street No. 186, Gongzhuling 136100, China.
Lei WangInstitute of Animal Husbandry and Veterinary Medicine, Jilin Academy of Agricultural Science, Kemao Street No. 186, Gongzhuling 136100, China.
Yu WangCollege of Animal Science and Technology, Jilin Agricultural University, Xincheng Street No. 2888, Changchun 130118, China.ORCID 0009-0008-6428-0626
Lizai LiuInstitute of Animal Husbandry and Veterinary Medicine, Jilin Academy of Agricultural Science, Kemao Street No. 186, Gongzhuling 136100, China.
Duojia WangInstitute of Animal Husbandry and Veterinary Medicine, Jilin Academy of Agricultural Science, Kemao Street No. 186, Gongzhuling 136100, China.
Xin ZhangInstitute of Animal Husbandry and Veterinary Medicine, Jilin Academy of Agricultural Science, Kemao Street No. 186, Gongzhuling 136100, China.
Luobing ZhaoInstitute of Animal Husbandry and Veterinary Medicine, Jilin Academy of Agricultural Science, Kemao Street No. 186, Gongzhuling 136100, China.
Yunhui ZhaoInstitute of Animal Husbandry and Veterinary Medicine, Jilin Academy of Agricultural Science, Kemao Street No. 186, Gongzhuling 136100, China.
Xiangshu JinInstitute of Animal Husbandry and Veterinary Medicine, Jilin Academy of Agricultural Science, Kemao Street No. 186, Gongzhuling 136100, China.
Xiaoxiao LiuInstitute of Animal Husbandry and Veterinary Medicine, Jilin Academy of Agricultural Science, Kemao Street No. 186, Gongzhuling 136100, China.
Hongxia MaCollege of Animal Science and Technology, Jilin Agricultural University, Xincheng Street No. 2888, Changchun 130118, China.ORCID 0000-0003-0165-4412

Funding

Jilin Province Agricultural Science and Technology Innovation Project CXGC2023RCG008Jilin Provincial Science and Technology Development Project YDZJ202203CGZH050, 20210202033NC, 20220202060NC, 20220202050NC, 20220502004GH
6 · The paper itself

Abstract

The worrying issue of antibiotic resistance in pathogenic bacteria is aggravated by the scarcity of novel therapeutic agents. Antibiotic adjuvants offer a promising solution due to their cost-effectiveness and high efficacy in addressing this issue, such as the β-lactamase inhibitor sulbactam (a β-lactam adjuvant) and the dihydrofolate reductase inhibitor trimethoprim (a sulfonamide adjuvant). This study aimed to discover potential adjuvants for tetracyclines from a list of previously approved drugs to restore susceptibility to

Indexed as

antibiotic adjuvantEscherichia coliguanethidinetetAtetracyclines

Identifiers

PMID39452239
PMCPMC11504368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.