Evidence map›Paper›PMID 39452118›Full record

ArticleBiology2024

Exercise Promotes Hippocampal Neurogenesis in T2DM Mice via Irisin/TLR4/MyD88/NF-κB-Mediated Neuroinflammation Pathway.

Haocheng Xu, Xin Tian, Yuanxin Wang, Junjie Lin, Baishu Zhu, Chen Zhao, Bin Wang, Xin Zhang, Yu Sun, Nan Li and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Haocheng XuCollege of Physical Education, Yangzhou University, Yangzhou 225127, China.ORCID 0000-0003-2369-305X
Xin TianCollege of Physical Education, Yangzhou University, Yangzhou 225127, China.
Yuanxin WangCollege of Physical Education, Yangzhou University, Yangzhou 225127, China.
Junjie LinCollege of Physical Education, Yangzhou University, Yangzhou 225127, China.ORCID 0000-0002-2252-0985
Baishu ZhuCollege of Physical Education, Yangzhou University, Yangzhou 225127, China.
Chen ZhaoCollege of Physical Education, Yangzhou University, Yangzhou 225127, China.
Bin WangCollege of Physical Education, Yangzhou University, Yangzhou 225127, China.
Xin ZhangCollege of Physical Education, Yangzhou University, Yangzhou 225127, China.
Yu SunCollege of Physical Education, Yangzhou University, Yangzhou 225127, China.
Nan LiCollege of Physical Education, Yangzhou University, Yangzhou 225127, China.
Xun SunCollege of Physical Education, Yangzhou University, Yangzhou 225127, China.
Fanxi ZengCollege of Physical Education, Yangzhou University, Yangzhou 225127, China.ORCID 0009-0005-4971-4412
Mingzhi LiCollege of Physical Education, Yangzhou University, Yangzhou 225127, China.
Xiquan YaCollege of Physical Education, Yangzhou University, Yangzhou 225127, China.
Renqing ZhaoCollege of Physical Education, Yangzhou University, Yangzhou 225127, China.ORCID 0000-0001-8901-9506

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation is a major feature of type 2 diabetic mellitus (T2DM), adversely affecting hippocampal neurogenesis. However, the precise mechanism is not fully understood, and therapeutic approaches are currently lacking. Therefore, we determined the effects of exercise on neuroinflammation and hippocampal neurogenesis in T2DM mice, with a specific focus on understanding the role of the irisin and related cascade pathways in modulating the beneficial effects of exercise in these processes. Ten-week exercise significantly decreased T2DM-induced inflammation levels and markedly promoted hippocampal neurogenesis and memory function. However, these positive effects were reversed by 10 weeks of treatment with cyclo RGDyk, an inhibitor of irisin receptor signaling. Additionally, exercise helped reduce the M1 phenotype polarization of hippocampal microglia in diabetic mice; this effect could be reversed with cyclo RGDyk treatment. Moreover, exercise markedly increased the levels of fibronectin type III domain-containing protein 5 (FNDC5)/irisin protein while decreasing the expression of Toll-like receptor 4 (TLR4), myeloid differential protein-88 (MyD88), and nuclear factor kappa-B (NF-κB) in the hippocampus of T2DM mice. However, blocking irisin receptor signaling counteracted the down-regulation of TLR4/MyD88/NF-κB in diabetic mice undergoing exercise intervention. Conclusively, exercise appears to be effective in reducing neuroinflammation and enhancing hippocampal neurogenesis and memory in diabetes mice. The positive effects are involved in the participation of the irisin/TLR4/MyD88/NF-κB signaling pathway, highlighting the potential of exercise in the management of diabetic-induced cognitive decline.

Indexed as

adult hippocampal neurogenesiscognitiondiabetesexerciseneuroinflammation

Identifiers

PMID39452118
PMCPMC11504848

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.