Evidence map›Paper›PMID 39451775›Full record

ReviewCurrent oncology (Toronto, Ont.)2024

Antibody-Drug Conjugates for the Treatment of Non-Small Cell Lung Cancer with Central Nervous System Metastases.

David J H Bian, Sara F Cohen, Anna-Maria Lazaratos, Nathaniel Bouganim, Matthew Dankner

Abstract readReview
In one paragraph

Review in Current oncology (Toronto, Ont.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

David J H BianDepartment of Internal Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3A 1G1, Canada.
Sara F CohenDepartment of Anatomy & Cell Biology, McGill University, Montreal, QC H3A 1G1, Canada.
Anna-Maria LazaratosFaculté de Médecine, Université de Montreal. Montreal, QC H3A 1G1, Canada.ORCID 0000-0003-4923-7159
Nathaniel BouganimDepartment of Oncology, McGill University Health Centre, Montreal, QC H3A 1G1, Canada.ORCID 0000-0003-0811-876X
Matthew DanknerDepartment of Internal Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3A 1G1, Canada.ORCID 0000-0003-4869-5895

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibody-drug conjugates (ADCs) represent an emerging class of targeted anticancer agents that have demonstrated impressive efficacy in numerous cancer types. In non-small cell lung cancer (NSCLC), ADCs have become a component of the treatment armamentarium for a subset of patients with metastatic disease. Emerging data suggest that some ADCs exhibit impressive activity even in central nervous system (CNS) metastases, a disease site that is difficult to treat and associated with poor prognosis. Herein, we describe and summarize the existing evidence surrounding ADCs in NSCLC with a focus on CNS activity.

Indexed as

Carcinoma, Non-Small-Cell LungCentral Nervous System NeoplasmsImmunoconjugatesLung NeoplasmsHumansImmunoconjugatesADCantibody–drug conjugatebrain metastasiscentral nervous system metastasislung cancernon-small-cell lung cancer

Identifiers

PMID39451775
PMCPMC11506643

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.