Evidence map›Paper›PMID 39451707›Full record

ArticleBiosensors2024

Fluorescence Immunoassay of Prostate-Specific Antigen Using 3D Paddle Screw-Type Devices and Their Rotating System.

Su Bin Han, Han Sol Kim, Young Ju Jo, Soo Suk Lee

Abstract read
In one paragraph

Article in Biosensors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Su Bin HanDepartment of Pharmaceutical Engineering, Soonchunhyang University, Asan 31538, Republic of Korea.
Han Sol KimDepartment of Pharmaceutical Engineering, Soonchunhyang University, Asan 31538, Republic of Korea.
Young Ju JoDepartment of Pharmaceutical Engineering, Soonchunhyang University, Asan 31538, Republic of Korea.
Soo Suk LeeDepartment of Pharmaceutical Engineering, Soonchunhyang University, Asan 31538, Republic of Korea.ORCID 0000-0003-0546-2709

Funding

National Research Foundation of Korea NRF-2022R1F1A1067428
6 · The paper itself

Abstract

In this paper, we present a sensitive and highly reproducible fluorescence immunosensor for detecting PSA in human serum. A unique feature of this study is that it uses creatively designed paddle screw-type devices and their custom-made rotating system for PSA immunoassay. The paddle screw devices were designed to maximize the surface-to-volume ratio over which the immunoassay reaction could occur to improve detection sensitivity. This paddle screw-based immunoassay offers an accessible and efficient method with a short analysis time of less than 30 min. Active rotation of the paddle screw plays a crucial role in fast and accurate analysis of PSA. Additionally, a paddle screw-based immunoassay and subsequent fluorescence detection using a custom prototype fluorescence detection system were compared to a typical well plate-based immunoassay system. Results of PSA detection in human serum showed that the detection sensitivity through the paddle screw-based analysis improved about five times compared to that with a well plate-based analysis.

Indexed as

Biosensing TechniquesProstate-Specific AntigenFluorescenceHumansImmunoassayMaleProstate-Specific Antigen3D paddle screwdetection sensitivityfluorescence measurementimmunoassayprostate-specific antigen

Identifiers

PMID39451707
PMCPMC11506760

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.