Evidence map›Paper›PMID 39451656›Full record

ArticleDiagnostics (Basel, Switzerland)2024

Chronic Diarrhea Owing to Microscopic Colitis: A Cohort Study with Insights into Diagnostic Challenges and Size of the Problem.

Ahmed Ibrahim Gad, Sara Mohamed Salem, Hanaa A Nofal, Hayam Rashed, Hossam Tharwat Ali, Noura Almadani, Rasha Mahfouz, Nevin F Ibrahim, Ayman M E M Sadek

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In one paragraph

Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ahmed Ibrahim GadInternal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.ORCID 0000-0001-9818-0078
Sara Mohamed SalemInternal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.
Hanaa A NofalCommunity, Environmental Occupational Medicine Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.ORCID 0000-0002-5909-4238
Hayam RashedPathology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.
Hossam Tharwat AliQena Faculty of Medicine, South Valley University, Qena 83621, Egypt.ORCID 0000-0001-8077-5911
Noura AlmadaniCommunity and Psychiatric Mental Health Nursing Department, College of Nursing, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.ORCID 0000-0003-1404-6854
Rasha MahfouzCommunity and Psychiatric Mental Health Nursing Department, College of Nursing, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
Nevin F IbrahimInternal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.ORCID 0000-0002-1007-2812
Ayman M E M SadekInternal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.ORCID 0000-0002-1095-1411

Funding

Princess Nourah bint Abdulrahman University PNURSP2024R347
6 · The paper itself

Abstract

backgroundMicroscopic colitis (MC) is a recognized cause of chronic diarrhea and is often underestimated when a colonoscopy appears normal. This study aims to accurately diagnose chronic diarrhea through histopathological examination of colonoscopic mucosal biopsies and assess the prevalence of microscopic colitis and the diagnostic value of biomarkers.

methodsA hospital-based cohort study was conducted on 116 patients with chronic diarrhea. Colonoscopies and colonic mucosal biopsies were performed and analyzed, along with various tests including fecal calprotectin (FC) level, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), stool analysis, routine laboratory tests, and clinical data related to nocturnal diarrhea, abdominal pain, and unexplained weight loss.

resultsIn the study group, 32.8% had MC, with 25.9% having lymphocytic colitis (LC) and 6.9% having collagenous colitis (CC). Patients with MC had significantly higher FC, ESR, and CRP levels than those without colitis (

conclusionsMicroscopic colitis, particularly LC-type, is not an uncommon cause of chronic diarrhea, especially when accompanied by symptoms such as abdominal pain and nocturnal diarrhea, warranting further investigation, including inflammatory markers and colonic biopsy. Inflammatory markers can be useful in diagnosing MC with proper values and approaches; however, further studies are needed.

Indexed as

chronic diarrheacolonoscopyfecal calprotectinmicroscopic colitis

Identifiers

PMID39451656
PMCPMC11507306

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.