Evidence map›Paper›PMID 39451542›Full record

ArticleCurrent issues in molecular biology2024

Quercetin as a Modulator of PTPN22 Phosphomonoesterase Activity: A Biochemical and Computational Evaluation.

Abdulhakeem Olarewaju Sulyman, Tafa Ndagi Akanbi Yusuf, Jamiu Olaseni Aribisala, Kamaldeen Sanni Ibrahim, Emmanuel Oladipo Ajani, Abdulfatai Temitope Ajiboye, Saheed Sabiu, Karishma Singh

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Article in Current issues in molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Dual PTP1B/DPP4 Inhibitory Potential ofComputational and structural biotechnology journal · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abdulhakeem Olarewaju SulymanDepartment of Biochemistry, Faculty of Pure and Applied Sciences, Kwara State University, Malete, Ilorin 241102, Nigeria.
Tafa Ndagi Akanbi YusufDepartment of Biochemistry, Faculty of Pure and Applied Sciences, Kwara State University, Malete, Ilorin 241102, Nigeria.
Jamiu Olaseni AribisalaDepartment of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban 1334, South Africa.
Kamaldeen Sanni IbrahimDepartment of Biochemistry, Faculty of Pure and Applied Sciences, Kwara State University, Malete, Ilorin 241102, Nigeria.
Emmanuel Oladipo AjaniDepartment of Biochemistry, Faculty of Pure and Applied Sciences, Kwara State University, Malete, Ilorin 241102, Nigeria.
Abdulfatai Temitope AjiboyeDepartment of Chemistry and Industrial Chemistry, Faculty of Pure and Applied Sciences, Kwara State University, Malete, Ilorin 241102, Nigeria.
Saheed SabiuDepartment of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban 1334, South Africa.
Karishma SinghDepartment of Nature Conservation, Faculty of Applied Sciences, Mangosuthu University of Technology, Durban 4031, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer, a group of diseases characterized by uncontrollable cell proliferation and metastasis, remains a global health challenge. This study investigates quercetin, a natural compound found in many fruits and vegetables, for its potential to inhibit the phosphomonoesterase activity of protein tyrosine phosphatase nonreceptor type 22 (PTPN22), a key immune response regulator implicated in cancer and autoimmune diseases. We started by screening seven (7) natural compounds against the activities of PTPN22 in vitro. The initial screening identified quercetin with the highest percentage inhibition (81%) among the screened compounds when compared with ursolic acid that has 84%. After the identification of quercetin, we proceeded by investigating the effect of increasing concentrations of the compound on the activity of PTPN22. In vitro studies showed that quercetin inhibited PTPN22 with an IC

Indexed as

cancerin vitro and in silico studiesPTPN22quercetin

Identifiers

PMID39451542
PMCPMC11506171

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.