Evidence map›Paper›PMID 39451246›Full record

ArticleCells2024

Early-Life Respiratory Syncytial Virus (RSV) Infection Triggers Immunological Changes in Gut-Associated Lymphoid Tissues in a Sex-Dependent Manner in Adulthood.

Stella Liong, Felicia Liong, Mitra Mohsenipour, Elisa L Hill-Yardin, Mark A Miles, Stavros Selemidis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stella LiongCentre for Respiratory Science and Health, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3082, Australia.ORCID 0000-0001-6131-858X
Felicia LiongCentre for Respiratory Science and Health, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3082, Australia.
Mitra MohsenipourSchool of Health and Biomedical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3082, Australia.ORCID 0000-0001-7290-543X
Elisa L Hill-YardinSchool of Health and Biomedical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3082, Australia.ORCID 0000-0002-4146-7198
Mark A MilesCentre for Respiratory Science and Health, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3082, Australia.ORCID 0000-0002-2162-2939
Stavros SelemidisCentre for Respiratory Science and Health, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3082, Australia.ORCID 0000-0002-3989-7615

Funding

National Health and Medical Research Council 2002948
6 · The paper itself

Abstract

Severe respiratory syncytial virus (RSV) infection during early life has been linked to gut dysbiosis, which correlates with increased disease severity and a higher risk of developing asthma later in life. However, the impact of such early-life RSV infections on intestinal immunity in adulthood remains unclear. Herein, we show that RSV infection in 3-week-old mice induced persistent differential natural killer (NK) and T cell profiles within the lungs and gastrointestinal (GI) lymphoid tissues (GALT) in adulthood. Notably, male mice exhibited more pronounced RSV-induced changes in immune cell populations in both the lungs and GALT, while female mice displayed greater resilience. Importantly, early-life RSV infection was associated with the chronic downregulation of CD69-expressing T lymphocytes, particularly T regulatory cells in Peyer's patches, which could have a significant impact on T cell functionality and immune tolerance. We propose that RSV infection in early life is a trigger for the breakdown in immune tolerance at mucosal surfaces, with potential implications for airways allergic disease, food allergies, and other GI inflammatory diseases.

Indexed as

LungLymphoid TissueRespiratory Syncytial Virus InfectionsAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensFemaleKiller Cells, NaturalLectins, C-TypeMaleMiceMice, Inbred C57BLPeyer's PatchesRespiratory Syncytial VirusesSex CharacteristicsAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensLectins, C-Typececal patchinflammationPeyer’s patchrespiratory syncytial virusT cells

Identifiers

PMID39451246
PMCPMC11506009

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.