Evidence map›Paper›PMID 39451197›Full record

ReviewCells2024

The Role of Soluble CD163 (sCD163) in Human Physiology and Pathophysiology.

Andriana Plevriti, Margarita Lamprou, Eleni Mourkogianni, Nikolaos Skoulas, Maria Giannakopoulou, Md Sanaullah Sajib, Zhiyong Wang, George Mattheolabakis, Antonios Chatzigeorgiou, Antonia Marazioti and 1 more

Registry-linked trialAbstract readReview
In one paragraph

Review in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07209748 (The Significance of Soluble CD163 as a Novel Biomarker in the Early Detection and Severity Assessment of HELLP Syndrome), which is not on this map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07209748 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Significance of Soluble CD163 as a Novel Biomarker in the Early Detection and Severity Assessment of HELLP Syndrome

TypeobservationalSponsorAssiut UniversityRan2025 to 2027Enrolled70ConditionsHELLP Syndrome Complicating PregnancyArmssCD163 level
3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Article
  3. Liver Macrophages in the Pathogenesis of Viral Hepatitis.Current issues in molecular biology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Cell-Cell Fusion as a Mechanism of Immune Evasion and Metastatic Progression.Advances in experimental medicine and biology · 2026
    Review
  16. Article
  17. Article
  18. SpaBalance: Balanced Learning for Efficient Spatial Multi-Omics Decoding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Andriana PlevritiLaboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504 Patras, Greece.
Margarita LamprouLaboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504 Patras, Greece.
Eleni MourkogianniLaboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504 Patras, Greece.
Nikolaos SkoulasLaboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504 Patras, Greece.
Maria GiannakopoulouLaboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504 Patras, Greece.
Md Sanaullah SajibDepartment of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.ORCID 0000-0002-8182-1681
Zhiyong WangStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou 310006, China.
George MattheolabakisSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.
Antonios ChatzigeorgiouDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece.ORCID 0000-0002-7039-4223
Antonia MaraziotiBasic Sciences Laboratory, Department of Physiotherapy, School of Health Sciences, University of Peloponnese, 23100 Sparta, Greece.
Constantinos M MikelisLaboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504 Patras, Greece.ORCID 0000-0002-6119-3307

Funding

Hellenic Foundation for Research and Innovation 00376
6 · The paper itself

Abstract

Soluble CD163 (sCD163) is a circulating inflammatory mediator, indicative of acute and chronic, systemic and non-systemic inflammatory conditions. It is the cleavage outcome, consisting of almost the entire extracellular domain, of the CD163, a receptor expressed in monocytic lineages. Its expression is proportional to the abundance of CD163

Indexed as

Antigens, CDAntigens, Differentiation, MyelomonocyticReceptors, Cell SurfaceAnimalsBiomarkersCD163 AntigenHumansInflammationMacrophagesSolubilityAntigens, CDAntigens, Differentiation, MyelomonocyticBiomarkersCD163 AntigenReceptors, Cell SurfacecancerCD163endothelial cellsphysiologysCD163soluble CD163

Identifiers

PMID39451197
PMCPMC11506427

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.