Trial reportAnaesthesiology intensive therapy2024
Do volatile anaesthetics depress urine output?
Trial report in Anaesthesiology intensive therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The physiologic power of fluid circulation and implications for fluid therapy.Frontiers in veterinary science · 2026Review
- Impact of Continuous Veno-Venous Hemodiafiltration on Thyroid Homeostasis in Critically Ill Patients.Journal of clinical medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionUrine output is markedly reduced by isoflurane, but it is unclear whether the decrease is a specific effect of volatile anaesthetics. Therefore, this study compared the diuretic response to crystalloid volume loading during surgical procedures performed with volatile anaesthetics or intravenous anaesthesia. MATERIAL AND
methodsData from two clinical trials in which patients were randomized between isoflurane and propofol anaesthesia (open thyroid surgery, n = 29) and between sevoflurane and propofol anaesthesia (open hysterectomy; n = 25) were analysed. Urine volume was measured and the diuretic response to volume loading with 1.7-1.8 L of Ringer's solution over 30 min was studied by population volume kinetic analysis. The kinetic method used 631 measurements of plasma dilution based on blood haemoglobin and plasma albumin and 138 measurements of urine output to quantify the diuretic response to volume loading in the four study groups.
resultsThe urine output after 150 min of thyroid surgery was 132 (77-231) mL in the propofol group and 218 (80-394) mL in the isoflurane group ( P = 0.50; median and interquartile range). The corresponding volumes were 50 (45-65) mL for propofol and 60 (34-71) mL for sevoflurane at 90 min in the hysterectomy patients ( P = 0.81). The kinetic analysis, which corrected for differences in infused volume, body weight, and plasma volume expansion, did not reveal any statistically significant differences in diuretic response to volume loading between the two inhaled anaesthetics and intravenous anaesthesia.
conclusionsIsoflurane and sevoflurane did not affect urine output more strongly than propofol.
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