ArticleNeuro-oncology2025
Prospective longitudinal analysis of physiologic MRI-based tumor habitat predicts short-term patient outcomes in IDH-wildtype glioblastoma.
Article in Neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Integrating Multimodal MRI Habitat and Transformer-Based Pathomics to Predict High-Risk Molecular Subtypes and Explore Biological Mechanisms in Adult Diffuse Gliomas.CNS neuroscience & therapeutics · 2026Article
- Distinguishing Molecular and Histologic Glioblastomas Using Multiparametric MRI-Based Habitat Analysis.Korean journal of radiology · 2026Article
- Advancing precision risk stratification in adult diffuse gliomas through DSC-MRI-based habitat analysis.BMC medical imaging · 2026Article
- Preoperative assessment of intratumor heterogeneity using intravoxel incoherent motion MRI for survival prediction in high-grade gliomas: a feasibility study.BMC medical imaging · 2026Article
- Multimodal MRI-based nomogram integrating clinical-radiological, radiomic, and habitat features to discriminate solitary fibrous tumors from atypical meningiomas.Scientific reports · 2026Article
- Cluster habitat-based diffusion MRI radiomics for differentiation of glioblastoma from solitary brain metastasis.European radiology experimental · 2026Article
- Temporal-spatial evolution of tumor habitat analysis: a bibliometric study on research hotspots and trends in medical imaging (2014-2025).Translational cancer research · 2026Article
- MRI-based habitat radiomics for predicting WHO/ISUP nuclear grade in clear cell renal cell carcinoma.Frontiers in oncology · 2026Article
- Evaluate lymphovascular space invasion in endometrial cancer using diffusion-weighted imaging-based habitat imaging.Scientific reports · 2025Article
- Habitat subregions analysis based on neurite orientation dispersion and density imaging enhances isocitrate dehydrogenase genotyping in glioma.BMC medical imaging · 2025Article
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9 authors.
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Abstract
backgroundThis study validates MRI-based tumor habitats in predicting time-to-progression (TTP), overall survival (OS), and progression sites in isocitrate dehydrogenase (IDH)-wildtype glioblastoma patients.
methodsSeventy-nine patients were prospectively enrolled between January 2020 and June 2022. MRI, including diffusion-weighted and dynamic susceptibility contrast imaging, were obtained immediately postoperation and at three serial timepoints. Voxels from cerebral blood volume and apparent diffusion coefficient maps were grouped into three habitats (hypervascular cellular, hypovascular cellular, and nonviable tissue) using k-means clustering. Predefined cutoffs for increases in hypervascular and hypovascular cellular habitat were applied to calculate the habitat risk score. Associations between spatiotemporal habitats, habitat risk score, TTP, and OS were investigated using Cox proportional hazards modeling. Habitat risk score was compared to tumor volume using time-dependent receiver operating characteristics analysis. Progression sites were matched with spatial habitats.
resultsIncreases in hypervascular and hypovascular cellular habitats and habitat risk scores were associated with shorter TTP and OS (all P < .05). Hypovascular cellular habitat and habitat risk scores 1 and 2 independently predicted TTP (hazard ratio [HR], 4.14; P = .03, HR, 4.51; P = .001 and HR, 10.02; P < .001, respectively). Hypovascular cellular habitat and habitat risk score 2 independently predicted OS (HR, 4.01, P = .003; and HR, 3.27, P < .001, respectively). Habitat risk score outperformed tumor volume in predicting TTP (12-month AUC, 0.762 vs. 0.646, P = .048). Hypovascular cellular habitat predicted progression sites (mean Dice index: 0.31).
conclusionsMultiparametric physiologic MRI-based spatiotemporal tumor habitats and habitat risk scores are useful biomarkers for early tumor progression and outcomes in IDH-wildtype glioblastoma patients.
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