Observational studyJournal of the American Heart Association2024
Stent Underexpansion Is an Underestimated Cause of Intrastent Restenosis: Insights From RESTO Registry.
Observational study in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04268875 (Morphological Parameters of In-stent RESTenosis Assessed and Identified by OCT), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Morphological Parameters of In-stent RESTenosis Assessed and Identified by OCT
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Management of under-expansion stent using intravascular lithotripsy under OCT guidance: a case report and systematic review.BMC cardiovascular disorders · 2025Pooled it
- Single-Cell Transcriptomics Reveals the Immune Pathogenesis of Isolated Coronary Arteritis Presenting as Refractory In-Stent Restenosis.JACC. Basic to translational science · 2026Article
- Optical Coherence Tomography for Recurrent Drug Eluting Stent-Related In-Stent Restenosis: Stepwise Intracoronary Imaging of Progressive Tissue and Calcium Modification.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Article
- The importance of post-dilatation during PCI: current evidence and future directions.Future cardiology · 2025Article
- Integrative cardiovascular disease therapy: Linoleic acid restriction, enhanced external counterpulsation, and emerging nanotherapies.World journal of cardiology · 2025Review
- Procedural and Antithrombotic Therapy Optimization in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A Narrative Review.Journal of cardiovascular development and disease · 2025Review
- Research advances in the etiology of in-stent restenosis of coronary arteries.Frontiers in cardiovascular medicine · 2025Review
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite improvement in devices, in-stent restenosis remains a frequent and challenging complication of percutaneous coronary interventions. METHODS AND
resultsThe RESTO (Morphological Parameters of In-Stent Restenosis Assessed and Identified by OCT [Optical Coherence Tomography]; study NCT04268875) was a prospective multicenter registry including patients presenting with coronary syndromes related to in-stent restenosis. All patients underwent preintervention OCT analysis, which led to analysis of in-stent restenosis phenotype, number of strut layers, and presence of stent underexpansion. The primary end point was the in-stent restenosis type according to the OCT morphological classification. The 1-year incidence of target vessel failure (a composite of death from cardiac causes, target-vessel myocardial infarction, or ischemia-driven target-vessel revascularization) was assessed. The study included 297 patients. The culprit stent was a drug-eluting stent in 74.2% of cases. OCT analysis revealed the presence of neoatherosclerosis in 57% (52% calcified), neointimal hyperplasia in 43% (58% homogeneous), stent underexpansion (minimal stent area <4.5 mm
conclusionsOCT identified neoatherosclerosis and neointimal hyperplasia in comparable proportions. Stent underexpansion was frequent and favored subsequent adverse clinical outcomes.
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