ArticleCurrent opinion in biomedical engineering2020
Growth and remodeling of atrioventricular heart valves: A potential target for pharmacological treatment?
Article in Current opinion in biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Sex-Specific Remodeling Phenotypes of the Tricuspid Valve Leaflets in an Ovine Model of Functional Tricuspid Regurgitation.bioRxiv : the preprint server for biology · 2026Article
- Leaflet remodeling reduces tricuspid valve function in a computational model.Journal of the mechanical behavior of biomedical materials · 2024Article
- A Computational Framework for Atrioventricular Valve Modeling Using Open-Source Software.Journal of biomechanical engineering · 2022Article
- Tricuspid chordae tendineae mechanics: Insertion site, leaflet, and size-specific analysis and constitutive modelling.Shi yan li xue = Journal of experimental mechanics · 2021Article
- Article
- Tricuspid Valve Annuloplasty Alters Leaflet Mechanics.Annals of biomedical engineering · 2020Article
- A pilot in silico modeling-based study of the pathological effects on the biomechanical function of tricuspid valves.International journal for numerical methods in biomedical engineering · 2020Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The atrioventricular heart valves, i.e., the mitral valve and the tricuspid valve, play vital roles in our cardiovascular system. Disease of these valves is therefore a significant source of morbidity and mortality. Unfortunately, current treatment options are suboptimal with significant rates of failure. It was only recently that we have begun to appreciate that the atrioventricular heart valve leaflets are not just passive flaps, but actively (mal-)adapting tissues. This discovery sheds new light on disease mechanisms and provides, thus, possible pathways to new treatments. In this current opinion piece, we examine the state of our knowledge about the (mal-)adaptive mechanisms (physiological and pathological growth and remodeling) of the atrioventricular heart valves. Furthermore, we review the evidence that suggests that valve maladaptation may be a target for pharmacological treatment of diseased valves which, in the future, could transform clinical practice.
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Registered trials
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