Evidence map›Paper›PMID 39450264›Full record

ArticleAdvanced optical materials2024

Noninvasive Injectable Optical Nanosensor-Hydrogel Hybrids Detect Doxorubicin in Living Mice.

Zachary Cohen, Dave J Alpert, Adam C Weisel, Amelia Ryan, Arantxa Roach, Syeda Rahman, Pooja V Gaikwad, Steven B Nicoll, Ryan M Williams

Abstract read
In one paragraph

Article in Advanced optical materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  7. High-throughput SWCNT NIR-II screening enables cell andbioRxiv : the preprint server for biology · 2026
    Article
  8. Article
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  10. Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zachary CohenThe City College of New York, Department of Biomedical Engineering, New York, NY 10031.
Dave J AlpertThe City College of New York, Department of Biomedical Engineering, New York, NY 10031.
Adam C WeiselThe City College of New York, Department of Biomedical Engineering, New York, NY 10031.
Amelia RyanThe City College of New York, Department of Biomedical Engineering, New York, NY 10031.
Arantxa RoachThe City College of New York, Department of Biomedical Engineering, New York, NY 10031.
Syeda RahmanThe City College of New York, Department of Biomedical Engineering, New York, NY 10031.
Pooja V GaikwadThe City College of New York, Department of Biomedical Engineering, New York, NY 10031.
Steven B NicollThe City College of New York, Department of Biomedical Engineering, New York, NY 10031.
Ryan M WilliamsThe City College of New York, Department of Biomedical Engineering, New York, NY 10031.

Funding

Training and Career Development CoreU54CA132378 · NCI · CITY COLLEGE OF NEW YORK · PI Tim Alan Ahles, ADRIANA ESPINOSA · 2008 to 2026
$28.9M
Training and Career Development and Education CoreU54CA137788 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Daniel Alan Heller · 2008 to 2026
$28.1M
Research Center in Minority Institutions (RCMI) at City CollegeU54MD017979 · NIMHD · CITY COLLEGE OF NEW YORK · PI M. Felice Marina GHILARDI · 2024 to 2026
$15.9M
G-RISE: Graduate Research Initiative for Student Advancement at The City College of New YorkT32GM136499 · NIGMS · CITY COLLEGE OF NEW YORK · PI RUTH E. STARK · 2020 to 2026
$4.9M
Integrating Real-Time Multi-System Cytokine Signaling in Chronic DiseaseR35GM142833 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI WILLIAMS, RYAN MARTIN · 2021 to 2025
$2.4M
NCI NIH HHS U54 CA132378NCI NIH HHS U54 CA137788NIGMS NIH HHS R35 GM142833NIGMS NIH HHS T32 GM136499NIMHD NIH HHS U54 MD017979
6 · The paper itself

Abstract

While the tissue-transparent fluorescence of single-walled carbon nanotubes (SWCNTs) imparts substantial potential for use in non-invasive biosensors, development of non-invasive systems is yet to be realized. Here, we investigated the functionality of a SWCNT-based nanosensor in several injectable SWCNT-hydrogel systems, ultimately finding SWCNT encapsulation in a sulfonated methylcellulose hydrogel optimal for detection of ions, small molecules, and proteins. We found that the hydrogel system and nanosensor signal were stable for several weeks in live mice. We then found that this system successfully detects local injections of the chemotherapeutic agent doxorubicin in mice. We anticipate future studies to adapt this device for detection of other analytes in animals and, ultimately, patients.

Indexed as

biosensingcarbon nanotubesdoxorubicinhydrogelimplantsin vivomethylcellulosemicenanosensorSWCNT

Identifiers

PMID39450264
PMCPMC11498898

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.