Evidence map›Paper›PMID 39450187›Full record

ArticleDrug target insights

Cytotoxic activity, selectivity, and clonogenicity of fruits and resins of Saudi medicinal plants against human liver adenocarcinoma.

Ali Hendi Alghamdi, Aimun A E Ahmed, Mahadi Bashir, Haidar Abdalgadir, Asaad Khalid, Mohamed E Abdallah, Riyad Almaimani, Bassem Refaat, Ashraf N Abdalla

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In one paragraph

Article in Drug target insights. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ali Hendi AlghamdiSurgery Department, Faculty of Medicine, Al-Baha University, Al Baha - Saudi Arabia.ORCID https://orcid.org/0000-0003-4451-3820
Aimun A E AhmedPharmacology Department, Faculty of Medicine, Al-Baha University, Al Baha - Saudi Arabia.ORCID https://orcid.org/0000-0002-6403-132X
Mahadi BashirSurgery Department, Faculty of Medicine, Al-Baha University, Al Baha - Saudi Arabia.ORCID https://orcid.org/0009-0004-4114-1253
Haidar AbdalgadirBiology Department, Faculty of Science, Al-Baha University, Al Baha - Saudi Arabia.
Asaad KhalidSubstance Abuse and Toxicology Research Center, Jazan University, Jazan - Saudi Arabia.ORCID https://orcid.org/0000-0001-8734-2588
Mohamed E AbdallahDepartment of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah - Saudi Arabia.
Riyad AlmaimaniDepartment of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah - Saudi Arabia.ORCID https://orcid.org/0000-0001-7944-2597
Bassem RefaatLaboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah - Saudi Arabia.ORCID https://orcid.org/0000-0003-4267-1016
Ashraf N AbdallaDepartment of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah - Saudi Arabia.ORCID https://orcid.org/0000-0003-4770-9319

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Edible fruits and resins provide various benefits to mankind including potential medicinal applications. This study aimed to determine the cytotoxicity, selectivity, and clonogenicity of fruits and exudates of certain Saudi medicinal plants ( Methods: Initial cytotoxicity and cell line selectivity against different cell lines were screened using MTT assay. The most promising extract was subjected to gas chromatography-mass spectrometry (GC-MS) analysis to determine the main phytoconstituents. Clonogenicity was checked for the most active extract. Results: The selected plants' fruits and resins possess a significant cytotoxic activity estimated as IC Conclusion: The fruits of BEP-10 have a potential cytotoxic effect particularly against HepG2. The identified phytoconstituents in the tested plant extract might contribute to the investigated cytotoxic activity.

Indexed as

ClonogenicityCytotoxicityMTT assayOpuntia ficus-indicaSaudi plantsSelectivity index

Identifiers

PMID39450187
PMCPMC11500103

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.