Evidence map›Paper›PMID 39450167›Full record

ArticleFrontiers in immunology2024

Intranasal sensitization model of alopecia areata using pertussis toxin as adjuvant.

Yuying Liu, Jasmin Freeborn, Beanna Okeugo, Shabba A Armbrister, Zeina M Saleh, Ana Beatriz Fadhel Alvarez, Thomas K Hoang, Evelyn S Park, John William Lindsey, Ronald P Rapini and 3 more

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuying LiuDivision of Pediatric Gastroenterology, Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Jasmin FreebornDivision of Pediatric Gastroenterology, Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Beanna OkeugoDivision of Pediatric Gastroenterology, Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Shabba A ArmbristerDivision of Pediatric Gastroenterology, Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Zeina M SalehDivision of Pediatric Gastroenterology, Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Ana Beatriz Fadhel AlvarezDivision of Pediatric Gastroenterology, Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Thomas K HoangDivision of Pediatric Gastroenterology, Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Evelyn S ParkDivision of Pediatric Gastroenterology, Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
John William LindseyDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Ronald P RapiniDepartments of Dermatology and Pathology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Steven GlazerILiAD Biotechnologies, Weston, FL, United States.
Keith RubinILiAD Biotechnologies, Weston, FL, United States.
Jon Marc RhoadsDivision of Pediatric Gastroenterology, Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Nasopharyngeal Methods: C57BL/6J female adult mice were given varied doses and schedules of intranasal PTx, MOG Results: Patchy alopecia developed in 36.4% of mice with the optimized protocol. Pathology consistent with alopecia areata was confirmed histologically by documenting concomitant reduced anagen phase and increased telogen phase hair follicles (HFs) in biopsies from patches of hair loss in mice with alopecia. We also found reduced CD200 staining and increased CD3 Conclusions: We propose that this is the first report of an autoimmune disease in an animal model triggered by colocalization of intranasal PTx and autoantigen. This model parallels a natural exposure and potential intranasal sensitization-to-pathology paradigm and supports the plausibility that nasopharyngeal subclinical BP colonization is a cause of alopecia areata.

Indexed as

Adjuvants, ImmunologicAdministration, IntranasalAlopecia AreataDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalMice, Inbred C57BLMyelin-Oligodendrocyte GlycoproteinPertussis ToxinAnimalsBordetella pertussisFemaleMicePeptide FragmentsWhooping CoughAdjuvants, ImmunologicMyelin-Oligodendrocyte Glycoproteinmyelin oligodendrocyte glycoprotein (35-55)Peptide FragmentsPertussis ToxinautoantigenautoimmunityBordetella pertussisimmunizationmyelin oligodendrocyte peptidenasopharyngeal colonization

Identifiers

PMID39450167
PMCPMC11499204

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.