ArticleCureus2024
Silent Damage by Micro-aspirations: Untangling the Connection of Gastroesophageal Reflux Disease (GERD) and Achalasia With Interstitial Lung Disease.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Aspiration and silent aspiration in Niemann-Pick disease type C1: longitudinal findings from the NIH natural history study.Orphanet journal of rare diseases · 2026Article
- Global Research Trends in Comorbidity Between Chronic Obstructive Pulmonary Disease and Gastro-Oesophageal Reflux Disease: A Bibliometric Study.International journal of chronic obstructive pulmonary disease · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastroesophageal reflux disease (GERD) frequently triggers respiratory conditions such as asthma and pneumonia. Inflammation occurs as a result of aspirated material, leading to symptoms such as cough, sputum production, chest discomfort from the involvement of the lower respiratory tract, and voice hoarseness owing to the involvement of the larynx. Repeated exposure to irritants can lead to fibrosis in the lungs. However, little is known about the association of achalasia with interstitial lung disease (ILD). We present a case of a patient with GERD who presented with cough and reflux for three months. Extensive testing confirmed the diagnosis of achalasia, and pneumatic dilation provided relief. The patient returned after two years with additional symptoms of shortness of breath. A CT scan of the chest showed worsening reticular changes and ground-glass opacity, indicative of ILD. An unremarkable toxin exposure history and a negative autoimmune panel led clinicians to explore the possible relationship between achalasia and ILD, highlighting the need for further exploration and research in this area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.