Evidence map›Paper›PMID 39449748›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2024

Optimization and validation of multi-echo, multi-contrast SAGE acquisition in fMRI.

Elizabeth G Keeling, Maurizio Bergamino, Sudarshan Ragunathan, C Chad Quarles, Allen T Newton, Ashley M Stokes

Abstract read
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elizabeth G KeelingBarrow Neuroimaging Innovation Center, Barrow Neurological Institute, Phoenix, AZ, United States.
Maurizio BergaminoBarrow Neuroimaging Innovation Center, Barrow Neurological Institute, Phoenix, AZ, United States.
Sudarshan RagunathanBarrow Neuroimaging Innovation Center, Barrow Neurological Institute, Phoenix, AZ, United States.
C Chad QuarlesBarrow Neuroimaging Innovation Center, Barrow Neurological Institute, Phoenix, AZ, United States.
Allen T NewtonVanderbilt University Institute of Imaging Science, Nashville, TN, United States.
Ashley M StokesBarrow Neuroimaging Innovation Center, Barrow Neurological Institute, Phoenix, AZ, United States.

Funding

MRI Assessment of Tumor Perfusion, Permeability and CellularityR01CA158079 · NCI · VANDERBILT UNIVERSITY · PI QUARLES, CHRISTOPHER CHAD · 2011 to 2021
$3.5M
Multi-scale functional connectivity in preclinical models of Parkinson's diseaseR01NS124575 · NINDS · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI Ashley M Stokes · 2022 to 2026
$2.0M
NCI NIH HHS R01 CA158079NINDS NIH HHS R01 NS124575
6 · The paper itself

Abstract

The purpose of this study was to optimize and validate a multi-contrast, multi-echo fMRI method using a combined spin- and gradient-echo (SAGE) acquisition. It was hypothesized that SAGE-based blood oxygen level-dependent (BOLD) functional MRI (fMRI) will improve sensitivity and spatial specificity while reducing signal dropout. SAGE-fMRI data were acquired with five echoes (2 gradient-echoes, 2 asymmetric spin-echoes, and 1 spin-echo) across 12 protocols with varying acceleration factors, and temporal SNR (tSNR) was assessed. The optimized protocol was then implemented in working memory and vision tasks in 15 healthy subjects. Task-based analysis was performed using individual echoes, quantitative dynamic relaxation times T

Indexed as

BOLD contrastBOLD contrast-to-noise ratio (CNR)functional MRI (fMRI)multi-echo fMRIspin-echo fMRI

Identifiers

PMID39449748
PMCPMC11497078

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.