Evidence map›Paper›PMID 39449680›Full record

ArticleHead & neck2025

Determining Factors Which Limit Resectability in Advanced Hypopharyngeal Malignancy.

Justin M Hintze, Eoin Cleere, Isobel O'Riordan, Conrad Timon, John Kinsella, Paul Lennon, Conall W R Fitzgerald

Abstract read
In one paragraph

Article in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Justin M HintzeDepartment of Otolaryngology-Head and Neck Surgery, St. James's Hospital, Dublin, Ireland.ORCID 0000-0002-7837-4032
Eoin CleereDepartment of Otolaryngology-Head and Neck Surgery, St. James's Hospital, Dublin, Ireland.ORCID 0000-0003-2750-3057
Isobel O'RiordanDepartment of Otolaryngology-Head and Neck Surgery, St. James's Hospital, Dublin, Ireland.
Conrad TimonDepartment of Otolaryngology-Head and Neck Surgery, St. James's Hospital, Dublin, Ireland.
John KinsellaDepartment of Otolaryngology-Head and Neck Surgery, St. James's Hospital, Dublin, Ireland.
Paul LennonDepartment of Otolaryngology-Head and Neck Surgery, St. James's Hospital, Dublin, Ireland.
Conall W R FitzgeraldDepartment of Otolaryngology-Head and Neck Surgery, St. James's Hospital, Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreoperative radiological findings of hypopharyngeal cancers are used to determine suitability for surgical resection. We sought to examine preoperative imaging characteristics to determine how well imaging findings predicted surgical resectability.

methodsA retrospective case-control study of patients undergoing a pharyngolaryngectomy in a tertiary referral center over a 2-year period was completed. Demographic details, previous treatment, subsite, TNM staging, imaging characteristics, and operative characteristics were collected.

resultsA total of 78 patients met initial inclusion criteria, of which 71 patients ultimately underwent successful surgical resection (91.1%). Preoperative images identified suspicion of prevertebral fascia invasion in 24 (30.7%) cases and carotid artery involvement in 14 (17.9%) cases. In cases of suspicion of prevertebral fascia invasion (24), 19 cases (79.2%) were resectable, and in those with carotid artery involvement (14), 11 (78.6%) were resectable. Concern for prevertebral fascia invasion on radiology led to a higher likelihood of a close margin (42% vs. 17%) in those without concerning features (p = 0.088).

conclusionsThe present study demonstrated a high rate of resectability of hypopharyngeal and upper esophageal cancers despite imaging findings suspicious for factors that could limit resectability. In patients with advanced hypopharyngeal, especially in the salvage setting, surgery should be considered.

Indexed as

Hypopharyngeal NeoplasmsLaryngectomyNeoplasm StagingPharyngectomyAdultAgedAged, 80 and overCarcinoma, Squamous CellCase-Control StudiesFemaleHumansMaleMiddle AgedNeoplasm InvasivenessRetrospective StudiesTomography, X-Ray Computedhypopharyngealprevertebral fasciaresectabilitySCC

Identifiers

PMID39449680
PMCPMC11717975

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.