Evidence map›Paper›PMID 39449421›Full record

ArticleJournal of xenobiotics2024

The Toxic Effects of Petroleum Diesel, Biodiesel, and Renewable Diesel Exhaust Particles on Human Alveolar Epithelial Cells.

Oskari J Uski, Gregory Rankin, Håkan Wingfors, Roger Magnusson, Christoffer Boman, Robert Lindgren, Ala Muala, Anders Blomberg, Jenny A Bosson, Thomas Sandström

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of xenobiotics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Oskari J UskiDepartment of Public Health and Clinical Medicine, Umeå University, 90187 Umeå, Sweden.ORCID 0009-0008-1862-8820
Gregory RankinDepartment of Public Health and Clinical Medicine, Umeå University, 90187 Umeå, Sweden.ORCID 0000-0002-8753-830X
Håkan WingforsCBRN Defence and Security, Swedish Defence Research Agency, 90182 Umeå, Sweden.ORCID 0000-0001-8847-9084
Roger MagnussonCBRN Defence and Security, Swedish Defence Research Agency, 90182 Umeå, Sweden.ORCID 0000-0002-4789-2929
Christoffer BomanDepartment of Applied Physics and Electronics, Thermochemical Energy Conversion Laboratory, Umeå University, 90187 Umeå, Sweden.ORCID 0000-0003-4428-3201
Robert LindgrenDepartment of Applied Physics and Electronics, Thermochemical Energy Conversion Laboratory, Umeå University, 90187 Umeå, Sweden.
Ala MualaDepartment of Public Health and Clinical Medicine, Umeå University, 90187 Umeå, Sweden.ORCID 0009-0009-2345-7584
Anders BlombergDepartment of Public Health and Clinical Medicine, Umeå University, 90187 Umeå, Sweden.ORCID 0000-0002-2452-7347
Jenny A BossonDepartment of Public Health and Clinical Medicine, Umeå University, 90187 Umeå, Sweden.
Thomas SandströmDepartment of Public Health and Clinical Medicine, Umeå University, 90187 Umeå, Sweden.

Funding

Swedish Heart Lung foundation (Hjärt-Lungfonden) 20230562Swedish Research Council for health working life and welfare (FORTE) 2015-00403Västerbotten County Council Spearhead Research grant (Västerbotten läns landsting) RV-363211
6 · The paper itself

Abstract

The use of alternative diesel fuels has increased due to the demand for renewable energy sources. There is limited knowledge regarding the potential health effects caused by exhaust emissions from biodiesel- and renewable diesel-fueled engines. This study investigates the toxic effects of particulate matter (PM) emissions from a diesel engine powered by conventional petroleum diesel fuel (SD10) and two biodiesel and renewable diesel fuels in vitro. The fuels used were rapeseed methyl ester (RME), soy methyl ester (SME), and Hydrogenated Vegetable Oil (HVO), either pure or as 50% blends with SD10. Additionally, a 5% RME blend was also used. The highest concentration of polycyclic aromatic hydrocarbon emissions and elemental carbon (EC) was found in conventional diesel and the 5% RME blend. HVO PM samples also exhibited a high amount of EC. A dose-dependent genotoxic response was detected with PM from SD10, pure SME, and RME as well as their blends. Reactive oxygen species levels were several times higher in cells exposed to PM from SD10, pure HVO, and especially the 5% RME blend. Apoptotic cell death was observed in cells exposed to PM from SD10, 5% RME blend, the 50% SME blend, and HVO samples. In conclusion, all diesel PM samples, including biodiesel and renewable diesel fuels, exhibited toxicity.

Indexed as

biodieselemissionshydrotreated vegetable oilin vitro toxicologyparticulate matterpetrodieselrapeseed methyl esterrenewable dieselsoy methyl ester

Identifiers

PMID39449421
PMCPMC11503417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.