Evidence map›Paper›PMID 39449319›Full record

ReviewJournal of developmental biology2024

Neural Circuit Remodeling: Mechanistic Insights from Invertebrates.

Samuel Liu, Kellianne D Alexander, Michael M Francis

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Samuel LiuDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0002-7082-6823
Kellianne D AlexanderDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Michael M FrancisDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0002-8076-6668

Funding

Molecular Analysis of Neural Circuit Excitation and InhibitionR01NS064263 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FRANCIS, MICHAEL M · 2009 to 2025
$5.5M
Investigating the Role of cnb-1 and chpf-1 in GABA DD Motor Neuron Remodeling and Synapse MaintenanceF31NS132495 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LIU, SAM · 2023 to 2025
$108k
NIH HHS 1F31NS132495-02A1NIH HHS 1R01NS064263-13A1NINDS NIH HHS F31 NS132495NINDS NIH HHS R01 NS064263
6 · The paper itself

Abstract

As nervous systems mature, neural circuit connections are reorganized to optimize the performance of specific functions in adults. This reorganization of connections is achieved through a remarkably conserved phase of developmental circuit remodeling that engages neuron-intrinsic and neuron-extrinsic molecular mechanisms to establish mature circuitry. Abnormalities in circuit remodeling and maturation are broadly linked with a variety of neurodevelopmental disorders, including autism spectrum disorders and schizophrenia. Here, we aim to provide an overview of recent advances in our understanding of the molecular processes that govern neural circuit remodeling and maturation. In particular, we focus on intriguing mechanistic insights gained from invertebrate systems, such as the nematode

Indexed as

C. eleganscell adhesioncellular activityDrosophilaneural circuitsremodelingsynapse eliminationtranscriptional regulation

Identifiers

PMID39449319
PMCPMC11503349

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.