ArticleJournal of health, population, and nutrition2024
Lowering the risk of hyperuricemia and gout is associated with ideal cardiovascular health.
Article in Journal of health, population, and nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Life's Essential 8 and cardiovascular health: Protective effects on chronic respiratory diseases.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Comparing the predictive accuracy of life's essential 8 and life's crucial 9 scores for all-cause mortality in COPD patients among US adults: a prospective cohort study.BMC public health · 2026Article
- The relationship between VAI, LAP, and depression and the mediation role of sleep duration-evidence from NHANES 2005-2020.BMC psychiatry · 2025Article
- Associations between life's essential 8 and preserved ratio impaired spirometry.Scientific reports · 2025Article
- Cross-sectional study on the association between serum uric acid levels and non-alcoholic fatty liver disease in an elderly population.Scientific reports · 2025Article
- Sex differences in the association between serum α-Klotho levels and hyperlipidemia: a cross-sectional study from NHANES 2013-2016.Scientific reports · 2025Article
- Exploring and validating associations between six systemic inflammatory indices and ischemic stroke in a middle-aged and old Chinese population.Aging clinical and experimental research · 2025Article
- Association between higher estimated glucose disposal rate and reduced prevalence of hyperuricemia and gout.Frontiers in nutrition · 2025Article
- Adherence to Life's Essential 8 is associated with lower risk of hyperuricemia among adults in Beijing, China.Frontiers in nutrition · 2025Article
- Correlation between lipid accumulation product and epigenetic age acceleration in American adults: a cross-sectional analysis using NHANES data.European journal of medical research · 2024Article
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12 authors.
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Abstract
backgroundHyperuricemia (HUA) and gout have been demonstrated as independent risk factors for cardiovascular disease. The relationship between the recently updated Life's Essentials 8 (LE8), which measures ideal cardiovascular health (CVH), and HUA and gout remains unclear. The aim of this study was to explore the relationship between CVH and the prevalence of HUA and gout among a nationally representative sample of US adults.
methodsThis study utilized cross-sectional analysis of data from the National Health and Nutrition Examination Survey (NHANES) for the years 2007 to 2018. The CVH scores and their corresponding components were defined according to the guidelines established by the American Heart Association. The association between the LE8 score and both HUA and gout was assessed using weighted multivariable logistic and restricted cubic spline (RCS) models.
resultsAmong the 21,155 participants aged 20 years and older, the prevalence of HUA was 17.20% (95% CI, 16.05-18.36%), and the prevalence of gout was 3.58% (95% CI, 3.13-4.02%). After adjusting for potential confounders, compared to participants exhibiting low CVH, the multivariable adjusted odds ratio (OR) for HUA was 0.65 (95% CI, 0.56-0.75) in those with moderate CVH, and 0.25 (95% CI, 0.20-0.31) in those with high CVH. Additionally, compared to participants with low CVH, the multivariable adjusted OR for gout was 0.66 (95% CI, 0.53-0.81) in those with moderate CVH and 0.32 (95% CI, 0.20-0.50) in those with high CVH. The LE8 score exhibited a significant nonlinear negative association with HUA and linear negative correlation with gout. In subgroup analyses focusing on HUA, significant interactions were observed between LE8 score and age, sex, and CKD (P for interaction < 0.05). For gout, only a significant interaction between LE8 score and sex was observed (P for interaction < 0.05).
conclusionsAmong adults, there was a significant negative correlation between LE8 score and the prevalence of HUA and gout. Maintaining an ideal CVH may be beneficial in reducing the burden of HUA and gout.
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