SynthesisEuropean journal of clinical nutrition2025
Higher dietary inflammatory index linked to increased risk of hypertension: a systematic review and dose-response meta-analysis.
Synthesis in European journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07309536 (Mediterranean Diet Uptake and Nutrition on Child Health, Inflammation, and Early-life Symbiosis), which is not on this map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mediterranean Diet Uptake and Nutrition on Child Health, Inflammation, and Early-life Symbiosis (MUNCHIES): A Randomized Controlled Trial
Who cites it
5 citing papers in PubMed.
- The Ketogenic Diet in the Prevention and Treatment of Hypertension (HTN).Biomedicines · 2026Review
- The Association Between Dietary Inflammatory Index with Metabolic Syndrome and Subclinical Atherosclerosis in Children and Adolescents: A Systematic Review.International journal of endocrinology and metabolism · 2026Article
- Association between hypertension and dietary inflammatory index among adults: a cross-sectional study in Hainan, China.Frontiers in nutrition · 2026Article
- Multicenter cohort study reveals: composite inflammatory indexs are associated with increased risk of diabetes in patients with hypertension.Frontiers in endocrinology · 2026Article
- Relationship Between Dietary Inflammatory Index, Diets, and Cardiovascular Medication.Nutrients · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between dietary inflammation index (DII) and the risk of hypertension is inconsistent across published epidemiological studies. This meta-analysis aimed to investigate the dose-response relationship between DII score and the risk of hypertension. A systematic search for relevant studies was conducted in PubMed, Web of Science, and Embase databases until January 9, 2024. After data extraction, the summarized relative risks (RRs) and 95% confidence intervals (95% CIs) were estimated using the Der Simonian and Laird random effect model, and dose-response analyses were performed using restricted cubic splines. A total of six studies with 120,294 participants and 36,725 cases of hypertension were included. The pooled relative risk (RR) for hypertension risk was 1.15 (95% CI: 1.06, 1.26) for the highest DII score compared with the lowest, and 1.10 (95% CI: 1.03, 1.18) for higher DII score compared with the lower. The dose-response meta-analysis further demonstrated a positive association between elevated DII scores and hypertension risk. For each one-unit increase in the DII score, the incidence of hypertension increased by 4% (RR = 1.04, 95% CI: 1.00, 1.07). Pro-inflammation dietary increases the risk of hypertension. Therefore, reducing pro-inflammatory components in the diet may be beneficial for the prevention and control of hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.