Evidence map›Paper›PMID 39448803›Full record

ArticleCancer gene therapy2024

SEMA7A-mediated juxtacrine stimulation of IGFBP-3 upregulates IL-17RB at pancreatic cancer invasive front.

Yi-Ing Chen, Sui-Chih Tien, Yi-Ling Ko, Chin-Chun Chang, Min-Fen Hsu, Hung Jen Chien, Hsuan-Yu Peng, Yung-Ming Jeng, Yun-Wen Tien, Yu-Ting Chang and 2 more

Erratum issuedAbstract read
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In one paragraph

Article in Cancer gene therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yi-Ing ChenGenomics Research Center, Academia Sinica, Taipei, Taiwan.
Sui-Chih TienGenomics Research Center, Academia Sinica, Taipei, Taiwan.
Yi-Ling KoGenomics Research Center, Academia Sinica, Taipei, Taiwan.
Chin-Chun ChangGenomics Research Center, Academia Sinica, Taipei, Taiwan.
Min-Fen HsuGenomics Research Center, Academia Sinica, Taipei, Taiwan.
Hung Jen ChienGenomics Research Center, Academia Sinica, Taipei, Taiwan.
Hsuan-Yu PengTMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.
Yung-Ming JengDepartment of Pathology, National Taiwan University Hospital, Graduate Institute of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID 0000-0002-9986-7194
Yun-Wen TienDepartment of Surgery, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID 0000-0002-9126-2705
Yu-Ting ChangDepartment of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
Ming-Chu ChangDepartment of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chun-Mei HuGenomics Research Center, Academia Sinica, Taipei, Taiwan. CMHU1220@gate.sinica.edu.tw.ORCID 0000-0002-4248-0896

Funding

Academia Sinica AS-GC-110-MD03Academia Sinica AS-KPQ-111-KNTMinistry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) NSTC 112-2326-B-001-007
6 · The paper itself

Abstract

Tumor invasion is the hallmark of tumor malignancy. The invasive infiltration pattern of tumor cells located at the leading edge is highly correlated with metastasis and unfavorable patient outcomes. However, the regulatory mechanisms governing tumor malignancy at the invasive margin remain unclear. The IL-17B/IL-17RB pathway is known to promote pancreatic cancer invasion and metastasis, yet the specific mechanisms underlying IL-17RB upregulation during invasion are poorly understood. In this study, we unveiled a multistep process for IL-17RB upregulation at the invasive margin, which occurs through direct communication between tumor cells and fibroblasts. Tumor ATP1A1 facilitates plasma membrane expression of SEMA7A, which binds to and induces IGFBP-3 secretion from fibroblasts. The resulting gradient of IGFBP-3 influences the direction and enhances IL-17RB expression to regulate SNAI2 in invasion. These findings highlight the importance of local tumor-fibroblast interactions in promoting cancer cell invasiveness, potentially leading to the development of new therapeutic strategies targeting this communication.

Indexed as

Antigens, CDInsulin-Like Growth Factor Binding Protein 3Neoplasm InvasivenessPancreatic NeoplasmsReceptors, Interleukin-17SemaphorinsUp-RegulationAnimalsCell Line, TumorGene Expression Regulation, NeoplasticGPI-Linked ProteinsHumansMiceAntigens, CDGPI-Linked ProteinsIGFBP3 protein, humanIL17RB protein, humanInsulin-Like Growth Factor Binding Protein 3Receptors, Interleukin-17SEMA7A protein, humanSemaphorins

Identifiers

PMID39448803
PMCPMC11645274

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.