ArticleNature communications2024
Measuring the dynamic balance of integration and segregation underlying consciousness, anesthesia, and sleep in humans.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed.
- Conserved neural dynamics of anesthesia and the oblivion of species.Nature neuroscience · 2026Article
- Evolution and Reorganization of the Hierarchical Brain-wide Neuronal Network Through Anesthesia.Neuroscience bulletin · 2026Article
- Differential Dynamic Reorganization of Functional Connectivity Based on Phase Synchrony and Amplitude Envelope Coupling During Propofol Sedation.Brain sciences · 2026Article
- Opposite network patterns of integration-segregation in psychedelic and sedated states of consciousness.Cell reports · 2026Article
- The Relationship Between the Functional Integration and Topological Complexity of Human Electroencephalographic (EEG) Signals: Three Moderating Factors.Brain sciences · 2026Article
- Article
- Reorganization of Human Brain Waves Across Diverse States of Consciousness.bioRxiv : the preprint server for biology · 2026Article
- Subcortical recruitment dissociates isoflurane emergence from distinct wakeful states in mice.bioRxiv : the preprint server for biology · 2026Article
- Neuroimaging of Disorder of Consciousness: From Brain Network Mechanisms to Clinical Translation.Journal of clinical neurology (Seoul, Korea) · 2026Review
- Movements During Intended General Anesthesia and Psychologically Traumatic Accidental Awareness: Explanatory Role of the "Efference Copy Network".Anesthesia and analgesia · 2026Article
- Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains.Nature human behaviour · 2026Article
- Characteristics of electroencephalographic changes induced by different hypnotics in elderly patients: a narrative review.Korean journal of anesthesiology · 2026Review
- Opposing Network Patterns of Integration-Segregation in Psychedelic and Sedated States of Consciousness.bioRxiv : the preprint server for biology · 2026Article
- Dexmedetomidine produces more sleep-like brain activity compared with propofol in human participants.British journal of anaesthesia · 2026Article
- An open fMRI resource for studying human brain function and covert consciousness under anesthesia.Scientific data · 2026Article
- Immediate large-scale cortical network changes following acupuncture in patients with disorders of consciousness: a resting-state fNIRS study.Frontiers in neuroscience · 2026Article
- Operating Room Professionals' Awareness of Possible Unconscious Auditory Perception During General Anesthesia: A Cross-Sectional Survey Study.Anesthesiology research and practice · 2026Article
- Neural Circuit Mechanisms of General Anaesthesia Induction: Current Advances and Future Directions.Current neuropharmacology · 2026Review
- Noradrenaline and acetylcholine shape functional connectivity organization of NREM substages: An empirical and simulation study.PLoS computational biology · 2025Article
- Functional connectivity and graph theory of impaired central visual pathways in acute ischemic stroke based on functional magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2025Article
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Abstract
Consciousness requires a dynamic balance of integration and segregation in brain networks. We report an fMRI-based metric, the integration-segregation difference (ISD), which captures two key network properties: network efficiency (integration) and clustering (segregation). With this metric, we quantify brain state transitions from conscious wakefulness to unresponsiveness induced by the anesthetic propofol. The observed changes in ISD suggest a profound shift towards the segregation of brain networks during anesthesia. A common unimodal-transmodal sequence of disintegration and reintegration occurs in brain networks during, respectively, loss and return of responsiveness. Machine learning models using integration and segregation data accurately identify awake vs. unresponsive states and their transitions. Metastability (dynamic recurrence of non-equilibrium transient states) is more effectively explained by integration, while complexity (diversity of neural activity) is more closely linked with segregation. A parallel analysis of sleep states produces similar findings. Our results demonstrate that the ISD reliably indexes states of consciousness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.