Evidence map›Paper›PMID 39448404›Full record

SynthesisSurgical endoscopy2024

Efficacy of endoscopic interventions versus surgery for pain management in patients with chronic calcific pancreatitis: a systematic review and meta-analysis.

Caleb Na, Tony He, Kareem Khalaf, Yuhong Yuan, Alessandro Fugazza, Shiva Jayaraman, Katarzyna M Pawlak, Sunil Gupta, Roxana Chis, Christopher W Teshima and 3 more

Abstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Surgical endoscopy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Caleb Na *Division of Gastroenterology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Tony He *Division of Gastroenterology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Kareem KhalafDivision of Gastroenterology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Yuhong YuanDepartment of Medicine, London Health Science Centre, London, ON, Canada.
Alessandro FugazzaDepartment of Gastroenterology, Endoscopy Unit, Humanitas Clinical and Research Centre IRCCS, Rozzano, Italy.
Shiva JayaramanHPB Surgery Service, Division of General Surgery, St. Joseph's Health Centre, Unity Health Toronto, Toronto, ON, Canada.
Katarzyna M PawlakDivision of Gastroenterology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Sunil GuptaDivision of Gastroenterology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Roxana ChisDivision of Gastroenterology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Christopher W TeshimaDivision of Gastroenterology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Jeffrey D MoskoDivision of Gastroenterology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Gary R MayDivision of Gastroenterology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Natalia Causada CaloDivision of Gastroenterology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada. natalia.ccalo@gmail.com.ORCID 0000-0003-3828-1031

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChronic calcific pancreatitis (CCP) is a debilitating inflammatory condition characterized by the accumulation of calcific deposits in the pancreatic tissue, leading to chronic abdominal pain and functional insufficiencies. This study aims to systematically review and meta-analyse comparative studies assessing the efficacy of endotherapy versus surgery in managing CCP-related pain.

methodsMEDLINE, EMBASE, and Cochrane library (CENTRAL and CDSR), from inception to October 2023, were searched. The inclusion criteria encompassed randomized controlled trials (RCTs) and non-randomized controlled trials (NRS), and cohort studies comparing endoscopic interventions to surgery for pain management in patients with CCP. Pain relief, procedural technical success, and procedural-related complications were the outcomes of interest. Two review authors (CN, KK) independently assessed study eligibility criteria and performed data extraction. Using a random-effects model, pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. The level of certainty of the evidence was assessed using the GRADE approach.

resultsFive studies were included. For the outcome of pain relief, a meta-analysis of five studies (3 RCTs and 2 cohort studies) demonstrated a significant therapeutic effect in favour of surgery with an OR of 2.36 (95% CI: 1.12 to 5.00, I

conclusionIn conclusion, this systematic review and meta-analysis suggest that surgery may be more effective in relieving pain in patients with CCP compared to endoscopic interventions. Disease stage may be important to determine the appropriateness of each procedure. PROSPERO (CRD42023476153).

Indexed as

Abdominal PainCalcinosisPain ManagementPancreatitis, ChronicHumansTreatment OutcomeChronic pancreatitisERCPLithotripsyPain managementPancreatic duct stentingPancreatic stone retrievalSphincterotomySurgery

Identifiers

PMID39448404

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.