Evidence map›Paper›PMID 39448400›Full record

ArticleActa neuropathologica2024

Autoantibodies to BACE1 promote Aβ accumulation and neurodegeneration in Alzheimer's disease.

Ye-Ran Wang, Xiao-Qin Zeng, Jun Wang, Christopher J Fowler, Qiao-Xin Li, Xian-Le Bu, James Doecke, Paul Maruff, Ralph N Martins, Christopher C Rowe and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Acta neuropathologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Role of aging‑related cytokines in neurodegenerative disease (Review).International journal of molecular medicine · 2026
    Review
  3. Article
  4. Article
  5. Pleiotropic regulatory mechanisms and targeted therapeutic prospects of Galectin-3 in aging-related diseases.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  6. Article
  7. The role of autoantibodies in Alzheimer's disease: Pathogenetic connections or epiphenomena?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ye-Ran Wang *Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
Xiao-Qin Zeng *Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
Jun WangDepartment of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
Christopher J FowlerThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Qiao-Xin LiThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Xian-Le BuDepartment of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
James DoeckeThe Australian E-Health Research Centre, CSIRO, Herston, QLD, Australia.
Paul MaruffThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Ralph N MartinsSchool of Medical Sciences, Sarich Neuroscience Research Institute, Edith Cowan University, Nedlands, WA, Australia.
Christopher C RoweDepartment of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.
Colin L MastersThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia. c.masters@unimelb.edu.au.
Yan-Jiang WangDepartment of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China. yanjiang_wang@tmmu.edu.cn.ORCID 0000-0002-6227-6112
Yu-Hui LiuDepartment of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China. yuhuiliu@tmmu.edu.cn.

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 81930028National-Level Reserve Talent Program of the Chongqing Health Commission HBRC202402National Natural Science Foundation of China 81971024National Natural Science Foundation of China 82222023
6 · The paper itself

Abstract

The profile of autoantibodies is dysregulated in patients with Alzheimer's disease (AD). Autoantibodies to beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) are present in human blood. This study aims to investigate the clinical relevance and pathophysiological roles of autoantibodies to BACE1 in AD. Clinical investigations were conducted in two independent cohorts, the Chongqing cohort, and the Australian Imaging, Biomarkers, and Lifestyle (AIBL) cohort. The Chongqing cohort included 55 AD patients, 28 patients with non-AD dementia, and 70 cognitively normal subjects (CN). The AIBL cohort included 162 Aβ-PET

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesAutoantibodiesMice, TransgenicAgedAged, 80 and overAmyloid beta-Protein PrecursorAnimalsBrainCohort StudiesFemaleHumansMaleMiceAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesAutoantibodiesBACE1 protein, humanBace1 protein, mouseAlzheimer’s diseaseAutoantibodiesAβ amyloidBACE1Cognitive impairment

Identifiers

PMID39448400

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.