Evidence map›Paper›PMID 39448202›Full record

ArticleJournal for immunotherapy of cancer2024

Targeting CD93 on monocytes revitalizes antitumor immunity by enhancing the function and infiltration of CD8

Da Jiang, Aiqi Huang, Bai-Xi Zhu, Jiangling Gong, Yong-Hao Ruan, Xing-Chen Liu, Limin Zheng, Yan Wu

Erratum issuedAbstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. The role of PD‑1/PD‑L1 axis in liver diseases.Clinical and experimental medicine · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Da Jiang *Sun Yat-sen University School of Life Science, Guangzhou, Guangdong, China.ORCID http://orcid.org/0000-0002-0483-2192
Aiqi Huang *Sun Yat-sen University School of Life Science, Guangzhou, Guangdong, China.ORCID http://orcid.org/0000-0002-4278-9463
Bai-Xi ZhuSun Yat-sen University School of Life Science, Guangzhou, Guangdong, China.ORCID http://orcid.org/0009-0001-8256-9772
Jiangling GongSun Yat-sen University School of Life Science, Guangzhou, Guangdong, China.ORCID http://orcid.org/0009-0009-6612-7809
Yong-Hao RuanSun Yat-sen University School of Life Science, Guangzhou, Guangdong, China.ORCID http://orcid.org/0000-0003-3467-6618
Xing-Chen LiuSun Yat-sen University School of Life Science, Guangzhou, Guangdong, China.ORCID http://orcid.org/0009-0007-5262-7461
Limin ZhengSun Yat-sen University School of Life Science, Guangzhou, Guangdong, China wuyan32@mail.sysu.edu.cn zhenglm@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-8281-1450
Yan WuSun Yat-sen University School of Life Science, Guangzhou, Guangdong, China wuyan32@mail.sysu.edu.cn zhenglm@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-9022-9794

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLimited activation and infiltration of CD8

methodsLevels of CD93 expression on monocytes from paired non-tumor, peritumor and tumor tissues of human hepatocellular carcinoma (HCC) were evaluated. The underlying mechanisms mediating effects of CD93

resultsIn this study, we found that monocytes in the peritumoral tissues of HCC significantly increased levels of CD93 expression, and these CD93

conclusionThis study identified an important mechanism contributing to the activation and limited infiltration of CD8

Indexed as

CD8-Positive T-LymphocytesMonocytesAnimalsCarcinoma, HepatocellularCell Line, TumorFemaleHumansLiver NeoplasmsMaleMembrane GlycoproteinsMiceReceptors, Complementcomplement 1q receptorMembrane GlycoproteinsReceptors, ComplementHepatocellular CarcinomaImmunotherapyMacrophageMonocyteTumor microenvironment - TME

Identifiers

PMID39448202
PMCPMC11499807

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.