Evidence map›Paper›PMID 39447944›Full record

Trial reportThe journal of pain2025

The use of abstract animations and a graphical body image for assessing pain outcomes among adults with sickle cell disease.

Julia A O'Brien, Charles R Jonassaint, Ektha Parchuri, Christina M Lalama, Sherif M Badawy, Megan E Hamm, Jennifer N Stinson, Chitra Lalloo, C Patrick Carroll, Santosh L Saraf and 13 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Julia A O'BrienDepartment of Acute and Tertiary Care, School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Charles R JonassaintDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: cjonassaint@pitt.edu.
Ektha ParchuriDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Christina M LalamaDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Sherif M BadawyDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Hematology, Oncology and Stem Cell Transplant, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Megan E HammDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Jennifer N StinsonLawrence S. Bloomberg, Faculty of Nursing, University of Toronto, Toronto, ON, Canada; Child Health Evaluation Sciences, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada; Institute for Health Policy, Management & Evaluation, University of Toronto, Toronto, Canada.
Chitra LallooChild Health Evaluation Sciences, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada; Institute for Health Policy, Management & Evaluation, University of Toronto, Toronto, Canada.
C Patrick CarrollJohns Hopkins Sickle Cell Center for Adults, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Santosh L SarafSickle Cell Center, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Victor R GordeukSickle Cell Center, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Robert M CroninDepartment of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Nirmish ShahSickle Cell Transition Program, Division of Hematology, Division of Pediatric Hematology/Oncology, Duke University, Durham, NC, USA.
Sophie M LanzkronJohns Hopkins Sickle Cell Center for Adults, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Darla LilesDepartment of Internal Medicine, East Carolina University, Greenville, NC, USA.
Cassandra TrimnellSickle Cell 101, San Jose, CA, USA.
Lakiea BaileySickle Cell Community Consortium, Atlanta, GA, USA.
Raymona LawrenceJiann Ping Hsu College of Public Health, Georgia Southern University, Savannah, GA, USA.
Leshana Saint JeanVanderbilt-Meharry Center of Excellence in Sickle Cell Disease, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael DeBaunVanderbilt-Meharry Center of Excellence in Sickle Cell Disease, Vanderbilt University Medical Center, Nashville, TN, USA.
Laura M De CastroDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Tonya M PalermoDepartment of Anesthesiology & Pain Medicine, University of Washington, and Seattle Children's Research Institute, Seattle, WA, USA.
Kaleab Z AbebeDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Technology Research in Chronic & Critical IllnessT32NR008857 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Young Ji Lee · 2005 to 2026
$4.0M
Designing an Implementation Strategy for Delivering Routine Mental Health Screening and Treatment for Adolescents and Adults with Sickle Cell DiseaseR34MH125152 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JONASSAINT, CHARLES RICHARD · 2020 to 2021
$706k
Adaptation and Pilot Testing of a Patient-provider Communication Intervention for Adults with Sickle Cell DiseaseK99NR020799 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI O'BRIEN, JULIA ANN · 2024 to 2025
$319k
NIMH NIH HHS R34 MH125152NINR NIH HHS K99 NR020799NINR NIH HHS T32 NR008857
6 · The paper itself

Abstract

Painimation, a novel digital pain assessment tool, allows patients to communicate their pain quality, intensity, and location using abstract animations (painimations) and a paintable body image. This study determined the construct validity of painimations and body image measures by testing correlations with validated pain outcomes in adults with sickle cell disease (SCD). Analyses used baseline data from a multisite randomized trial of 359 adults with SCD and chronic pain. Participants completed questionnaires on demographics, pain severity, frequency and interference, catastrophizing, opioid use, mood and quality of life, plus the Painimation app. Participants were categorized by selected painimations, and were split into groups based on the proportion of painted body image. Potential confounding was evaluated by age, gender, race, education, disability, site, depression, and anxiety. The 'shooting' painimation was strongly associated with daily pain intensity, pain interference, frequency, and severity. 'Electrifying' was associated with daily pain and opioid misuse, while greater body area in pain correlated with worse outcomes across all pain measures. Both painimations and body image measures correlated with validated pain outcomes, quality of life and mental health measures. This demonstrates animations and body image data can assess SCD pain severity, potentially with more accuracy than a 0-10 scale. Future research will explore whether Painimation can differentiate biological and psychosocial pain components. PERSPECTIVE: This article presents the preliminary construct validity of Painimation in SCD by examining the associations of "painimations" and body area image data with daily e-diary and traditional self-report pain outcomes.

Indexed as

Anemia, Sickle CellBody ImageChronic PainPain MeasurementAdultFemaleHumansMaleMiddle AgedQuality of LifeYoung AdultEcological momentary assessmenteHealthMental healthmHealthPainSickle cell disease

Identifiers

PMID39447944
PMCPMC12286575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.