Evidence map›Paper›PMID 39447830›Full record

ArticleFertility and sterility2025

Antibody-dependent complement-mediated sperm cytotoxicity in the endocervix is a dominant contraceptive mechanism of ZB-06 vaginal film.

Ellena Nador, Emilie Mausser, Jai G Marathe, Joseph A Politch, Andrea R Thurman, Kevin J Whaley, Deborah J Anderson

Abstract read
In one paragraph

Article in Fertility and sterility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Complement protein concentrations and activity in human cervical mucus.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ellena NadorDepartment of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts.
Emilie MausserDepartment of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts.
Jai G MaratheDepartment of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts.
Joseph A PolitchDepartment of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts.
Andrea R ThurmanDare Bioscience, San Diego, California.
Kevin J WhaleyZabBio, San Diego, California.
Deborah J AndersonDepartment of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts. Electronic address: deborah.anderson@bmc.org.

Funding

Project 3: Film Formulation, PK/PD and Safety Studies of ZB-06P50HD096957 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ANDERSON, DEBORAH J, WHALEY, KEVIN · 2019 to 2025
$12.9M
Synthetic mRNA-mediated reversible immunocontraceptionR33HD099745 · NICHD · EMORY UNIVERSITY · PI ANDERSON, DEBORAH J, SANTANGELO, PHILIP J · 2021 to 2023
$2.0M
NICHD NIH HHS P50 HD096957NICHD NIH HHS R33 HD099745
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39447830
PMCPMC12269741

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.