Evidence map›Paper›PMID 39447579›Full record

ArticleExperimental physiology2024

Ventilatory response to head-down-tilt in healthy human subjects.

Abdulaziz Alsharifi, Niamh Carter, Akbar Irampaye, Charlotte Stevens, Elisa Mejia, Joerg Steier, Gerrard F Rafferty

Registry-linked trialAbstract read
In one paragraph

Article in Experimental physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07396701 (Chinese Adaptive Randomised Pneumonia Trial With Respiratory Failure), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07396701 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Chinese Adaptive Randomised Pneumonia Trial With Respiratory Failure

TypeinterventionalSponsorPeking Union Medical College HospitalRan2026 to 2028Enrolled1,500ConditionsSevere Pneumonia With Respiratory FailureArmsTrendelenburg Position, Traditional Chinese Medicine Formulation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abdulaziz AlsharifiCentre for Human and Applied Physiological Sciences (CHAPS), Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID https://orcid.org/0000-0001-7535-3378
Niamh CarterCentre for Human and Applied Physiological Sciences (CHAPS), Faculty of Life Sciences and Medicine, King's College London, London, UK.
Akbar IrampayeCentre for Human and Applied Physiological Sciences (CHAPS), Faculty of Life Sciences and Medicine, King's College London, London, UK.
Charlotte StevensCentre for Human and Applied Physiological Sciences (CHAPS), Faculty of Life Sciences and Medicine, King's College London, London, UK.
Elisa MejiaCentre for Human and Applied Physiological Sciences (CHAPS), Faculty of Life Sciences and Medicine, King's College London, London, UK.
Joerg SteierCentre for Human and Applied Physiological Sciences (CHAPS), Faculty of Life Sciences and Medicine, King's College London, London, UK.
Gerrard F RaffertyCentre for Human and Applied Physiological Sciences (CHAPS), Faculty of Life Sciences and Medicine, King's College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postural fluid shifts may directly affect respiratory control via a complex interaction of baro- and chemo-reflexes, and cerebral blood flow. Few data exist concerning the steady state ventilatory responses during head-down tilt. We examined the cardiorespiratory responses during acute 50° head-down tilt (HDT) in 18 healthy subjects (mean [SD] age 27 [10] years). Protocol 1 (n = 8, two female) was 50° HDT from 60° head-up posture sustained for 10 min, while exposed to normoxia, normoxic hypercapnia (5% CO

Indexed as

Cerebrovascular CirculationHead-Down TiltHypercapniaAdultBlood Flow VelocityBlood PressureCarbon DioxideFemaleHealthy VolunteersHumansHypoxiaMaleMiddle Cerebral ArteryPulmonary VentilationRespirationYoung AdultCarbon Dioxidebaroreceptorscerebral blood flowchemoreceptorshead‐down tiltrespiratory controlTrendelenburg positionventilation

Identifiers

PMID39447579
PMCPMC11607625

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.