Evidence map›Paper›PMID 39447490›Full record

ArticleNeurobiology of aging2025

Amyloid pathology and cognitive impairment in hAβ-KI and APP

Wenyan Lu, Francis Shue, Aishe Kurti, Suren Jeevaratnam, Jesse R Macyczko, Bhaskar Roy, Taha Izhar, Ni Wang, Guojun Bu, Takahisa Kanekiyo and 1 more

Abstract read
In one paragraph

Article in Neurobiology of aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Metabolic Shifts Precede Cognitive Decline in the Male hAß-KI Alzheimer's Mouse Model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Characterization of adult hippocampal neurogenesis in the novelbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wenyan LuDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Francis ShueDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Aishe KurtiDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Suren JeevaratnamDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Jesse R MacyczkoDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Bhaskar RoyDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Taha IzharDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Ni WangDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Guojun BuDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Takahisa KanekiyoDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Yonghe LiDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. Electronic address: Li.Yonghe@mayo.edu.

Funding

Discovery of apoE4 modulators for Alzheimer’s disease therapyR01AG078615 · NIA · MAYO CLINIC JACKSONVILLE · PI CHUNG, THOMAS D Y, LI, YONGHE · 2022 to 2025
$1.8M
Novel Wnt activators for Alzheimer's disease therapyR21AG065653 · NIA · MAYO CLINIC JACKSONVILLE · PI LI, YONGHE · 2020 to 2020
$430k
NIA NIH HHS R01 AG078615NIA NIH HHS R21 AG065653
6 · The paper itself

Abstract

The hAβ-KI and APP

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorDisease Models, AnimalMice, TransgenicAnimalsBrainCognition DisordersFemaleHomozygoteHumansMaleMiceMutationPlaque, AmyloidAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid β (Aβ)APP(SAA)-KI miceCognitive impairmentHAβ-KI miceSex-dependent effects

Identifiers

PMID39447490
PMCPMC11578766

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.