Evidence map›Paper›PMID 39447157›Full record

ArticleEuropean journal of neurology2024

Plasma phosphorylated tau181 outperforms [

Kely Monica Quispialaya, Joseph Therriault, Antonio Aliaga, Cécile Tissot, Stijn Servaes, Nesrine Rahmouni, Thomas K Karikari, Andrea L Benedet, Nicholas J Ashton, Arthur C Macedo and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Article
  5. Article
  6. Plasma phosphorylated tau181 outperforms [European journal of neurology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Kely Monica QuispialayaTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.ORCID https://orcid.org/0009-0000-6982-7143
Joseph TherriaultTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
Antonio AliagaTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
Cécile TissotTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
Stijn ServaesTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
Nesrine RahmouniTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
Thomas K KarikariDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Andrea L BenedetTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
Nicholas J AshtonDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Arthur C MacedoTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
Firoza Z LussierTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
Jenna StevensonTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
Yi-Ting WangTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
Jaime Fernandez AriasTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
Ali HosseiniTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
Takashi MatsudairaDepartment of Biofunctional Imaging, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Bertrand Jean-ClaudeDepartment of Experimental Medicine, McGill University, Montreal, Quebec, Canada.
Brian M GilfixDepartment of Specialized Medicine, McGill University, Montreal, Quebec, Canada.
Eduardo R ZimmerTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
Jean-Paul SoucyMontreal Neurological Institute, Montreal, Quebec, Canada.
Tharick A PascoalDepartment of Neurology and Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Serge GauthierTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Pedro Rosa-NetoTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.ORCID https://orcid.org/0000-0001-9116-1376
Alzheimer's Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI Nicholas Ashton · 2021 to 2026
$24.9M
Plasma brain-derived tau: a novel Alzheimer’s disease-type neurodegeneration biomarker with potential to complete the AT(N) scheme in bloodR01AG083874 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas K Karikari · 2023 to 2026
$14.5M
Alzheimer's Association NIRG-12-92090Alzheimer's Association NIRP-12-259245Brain Canada Foundation CFI Project 34874; 33397Canadian Consortium of Neurodegeneration and Aging CCNA; MOP-11-51-31 -team 1CIHR MOP-11-51-31; RFN 152985, 159815, 162303Fonds de Recherche du Québec - Santé FRQS; Chercheur Boursier, 2020-VICO-279314NIA NIH HHS P30 AG072980NIA NIH HHS R01 AG083874NIA NIH HHS U01 AG024904Weston Brain Institute
6 · The paper itself

Abstract

background and purposeThis study was undertaken to compare the performance of plasma p-tau181 with that of [

methodsWe included 533 cognitively impaired participants from the Alzheimer's Disease Neuroimaging Initiative. Participants underwent PET scans, biofluid collection, and cognitive tests. Receiver operating characteristic analyses were used to determine the diagnostic accuracy of plasma p-tau181 and [

resultsWe observed that both plasma p-tau181 and [

conclusionsOverall, although both plasma p-tau181 and [

Indexed as

Alzheimer DiseaseBiomarkersFluorodeoxyglucose F18Positron-Emission Tomographytau ProteinsAgedAged, 80 and overAmyloid beta-PeptidesCognitive DysfunctionEarly DiagnosisFemaleHumansMaleMiddle AgedPhosphorylationRadiopharmaceuticalsAmyloid beta-PeptidesBiomarkersFluorodeoxyglucose F18MAPT protein, humanRadiopharmaceuticalstau Proteins[18F]FDG‐PET[18F]florbetapir‐PETAlzheimer diseasecerebrospinal fluidplasma p‐tau181

Identifiers

PMID39447157
PMCPMC11555153

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.