Evidence map›Paper›PMID 39447118›Full record

ArticleAmerican journal of physiology. Renal physiology2025

Sex differences in the adrenal circadian clock: a role for BMAL1 in the regulation of urinary aldosterone excretion and renal electrolyte balance in mice.

Hannah M Costello, Sophia A Eikenberry, Kit-Yan Cheng, Bryanna Broderick, Advay S Joshi, Gianna R Scott, Annalisse McKee, Victor M Mendez, Lauren G Douma, G Ryan Crislip and 1 more

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hannah M CostelloDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.
Sophia A EikenberryDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.
Kit-Yan ChengDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.
Bryanna BroderickDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.ORCID 0009-0003-5118-7178
Advay S JoshiDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.
Gianna R ScottDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.
Annalisse McKeeDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.
Victor M MendezDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.
Lauren G DoumaDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.ORCID 0000-0001-8216-9253
G Ryan CrislipDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.
Michelle L GumzDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.ORCID 0000-0002-1342-0878

Funding

Per1 and the kidney clock in hypertensionR01DK109570 · NIDDK · UNIVERSITY OF FLORIDA · PI GUMZ, MICHELLE L · 2017 to 2021
$1.5M
The Role of Sex Hormones in Distal Nephron-Specific BMAL1 Blood Pressure Regulation in Male and Female MiceF32DK121424 · NIDDK · UNIVERSITY OF FLORIDA · PI CRISLIP, GENE RYAN · 2019 to 2021
$130k
American Heart Association (AHA) 19EIA34660135American Heart Association (AHA) P0240441HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) F32DK121424NIDDK NIH HHS F32 DK121424NIDDK NIH HHS R01 DK109570
6 · The paper itself

Abstract

Brain and muscle ARNT-Like 1 (BMAL1) is a circadian clock transcription factor that regulates physiological functions. Male adrenal-specific

Indexed as

Adrenal GlandsAldosteroneARNTL Transcription FactorsCircadian ClocksKidneyMice, KnockoutWater-Electrolyte BalanceAnimalsCircadian RhythmDiet, Sodium-RestrictedFemaleMaleMiceMice, Inbred C57BLRenal EliminationSex CharacteristicsAldosteroneARNTL Transcription FactorsBmal1 protein, mouseSodiumadrenal glandbrain and muscle ARNT-like 1circadian rhythmskidneysex differences

Identifiers

PMID39447118
PMCPMC12352493

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.