ArticleNeurology2024
Prevalence and Clinical Implications of Hemosiderin Deposits in Recent Small Subcortical Infarcts.
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Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Risk factors and prediction model of dysphagia in patients with recent small subcortical infarct.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Dual-modal super-resolution ultrasound and NIR-II fluorescence imaging of ischemic stroke with ICG-doped porous PLGA microspheres.Materials today. Bio · 2025Article
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16 authors.
Yu-Yuan XuFrom the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.ORCID 0000-0002-7109-1283
Francesca M ChappellFrom the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.ORCID 0000-0002-7742-1757
Maria Del C Valdés HernándezFrom the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.ORCID 0000-0003-2771-6546
Carmen Arteaga-ReyesFrom the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.ORCID 0000-0003-2424-7123
Una ClancyFrom the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.ORCID 0000-0002-8062-7537
Daniela Jaime GarciaFrom the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.ORCID 0000-0002-9457-9855
Stewart WisemanFrom the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.ORCID 0000-0001-6739-5797
Michael S StringerFrom the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.ORCID 0000-0002-3811-4439
Michael ThrippletonFrom the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.ORCID 0000-0001-7858-9917
Yajun ChengFrom the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.ORCID 0000-0002-5227-9811
Junfang ZhangFrom the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.ORCID 0000-0001-5969-4789
Xiaodi LiuFrom the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.ORCID 0000-0003-3091-1932
Angela C C JochemsFrom the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.ORCID 0000-0001-7392-3066
Fergus DoubalFrom the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.ORCID 0000-0002-2769-3148
Joanna M WardlawFrom the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.ORCID 0000-0002-9812-6642
MSS3 Study GroupFrom the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesA quarter of ischemic strokes are of lacunar clinical subtype and have an underlying recent small subcortical infarct (RSSI), but their long-term outcomes remain poorly characterized. Hemosiderin deposits (HDs) have been noted in RSSIs at chronic stages and might mimic primary hemorrhage. We characterized HDs' morphology, frequency, and clinical relevance.
methodsParticipants with RSSIs were identified from a prospective longitudinal study and evaluated on 3T MRI including susceptibility-weighted imaging (SWI) from stroke diagnosis to 12 months. We categorized HDs in RSSIs on SWI at all available time points into 4 types (spots, smudge, rim, cluster) and assessed their associations with demographic factors, stroke-related factors, and image markers with adjusted logistic regression.
resultsHDs were observed in 43 (55.0%) of 108 participants within 3 months and 83 (76.9%) of 108 within 12 months after stroke onset. The mean time to first detection of HDs was 87 (interquartile range 53-164) days. A "rim" pattern (similar to late appearance of primary hemorrhage) occurred in at least 26.5% of RSSIs at all follow-up time points, mainly those located in the lentiform/internal capsule (50.0%) or thalamus (36.4%). Infarct volume (odds ratio [OR] 1.003, 95% CI 1.001-1.006; DISCUSSION: HDs occur commonly in RSSIs and may be associated with infarct volume and SVD score. Hemosiderin "rim" is common in RSSIs, urging caution to avoid mistaking ischemic RSSI for primary hemorrhage in subacute and chronic stages.
Indexed as
HemosiderinMagnetic Resonance ImagingAgedCerebral InfarctionFemaleHumansLongitudinal StudiesMaleMiddle AgedPrevalenceProspective StudiesHemosiderin
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